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Thalidomid

A much more serious drawback to using chiral drugs as racemic mixtures is illustrated by thalidomide briefly employed as a sedative and antinausea drug in Europe during the period 1959-1962 The desired properties are those of (/ ) thalidomide (S) Thalido mide however has a very different spectrum of bio logical activity and was shown to be responsible for over 2000 cases of serious birth defects in children born to women who took it while pregnant... [Pg.296]

Bromocresol green (3.8...5.4) aliphatic carboxylic acids[103,187 — 204] triiodobenzoic acid [205], derivatives of barbituric acid [206] amphetamine derivatives [207, 208] phenazones, morazone [209] alkaloids [91, 209] nephopam [210] phenyramidol metabolites [211] diethylalkylacetamide derivatives [212] zipeprol (Mirsol) [213] thalidomide and hydrolysis products [214] cyclohexylamine derivatives [215] herbicide residues [216]... [Pg.45]

Development of novel response modifiers derived from thalidomide (3-phthaIimidopyridine-2,6-dione) and other phthalimide derivatives 99 YGK94. [Pg.234]

The glutarimide best known to the lay public, thalidomide (40), owes its reputation not to efficacy, but to the wholly unanticipated and tragic teratogenic effects elicited by this compound. It might be noted that the very efficacy and lack of the usual barbiturate side effects shown by this drug led to its prescription as a hypnotic for expectant mothers. Condensation of the phthalimide of glutamic acid (39) with ammonia at elevated... [Pg.257]

One enantiomer of penicillamine (D-) exhibits antiarthritic properties but foe other is highly toxic (Figure 8.3). The teratogenic effects of thalidomide were induced by one enantiomer, foe other exhibited foe beneficial effects against morning sickness. [Pg.239]

Thalidomide Polycyclic teratogen, antiangiogenic mechanism unknown... [Pg.85]

Cj H403 85-44-9) sec Anisindione Chlortalidone Cilazapril Deptropine Fluorescein Hydralazine Indobufen Indoprofen Melphalan Phenolphthalein Phthalylsulfathiazole Pizotifen Pramipexole hydrochloride Saquinavir Sulfaloxic acid Thalidomide Tilisolol hydrochloride phthalide... [Pg.2435]

CH4N2O 57-13-6) see Alfuzosin Allantoin Amobarbital Barbital Bromisoval Butalbital Carbasalate calcium Carbromal Cyclopentobarbital Dimethadione Dipyridamole Enoximone Ethotoin Heptabarb Metaxalone Methyclothiazide Orotic acid Paramethadione Pentobarbital Phenacemide Phenetuiide Phenobarbital Phenytoin Proquazone Secbutabarbital Secobarbital Sulfadimethoxine Thalidomide Trimethadione... [Pg.2453]

Tetrahydrocannabinol (= THC)-11-carboxylic acid 290 Tetrahydrocortiso 221 Tetrahydrocortisone 221 Tetrahydrosteroids 222 Tetrazolium salts, reduction 61 Thalidomide 45 -, hydrolysis products 45 Thiabendazole 307, 308 Thiamine 235, 236, 397 Thickening agents 179 Thin-layer chromatography, advantage 5 -, numbers of publications per year 6 Thiobarbiturates 45,66 Thiocarbamide derivatives 322 Thiocarbamides, N -ary I-N -benzenesulfo-nyl- 248,249 Thiochrome 395... [Pg.734]


See other pages where Thalidomid is mentioned: [Pg.77]    [Pg.296]    [Pg.980]    [Pg.980]    [Pg.857]    [Pg.550]    [Pg.313]    [Pg.314]    [Pg.315]    [Pg.5]    [Pg.296]    [Pg.446]    [Pg.277]    [Pg.203]    [Pg.340]    [Pg.86]    [Pg.213]    [Pg.38]    [Pg.290]    [Pg.8]    [Pg.11]    [Pg.2005]    [Pg.2006]    [Pg.2006]    [Pg.2280]    [Pg.2294]    [Pg.2321]    [Pg.2390]    [Pg.2391]    [Pg.2435]    [Pg.2435]    [Pg.2435]    [Pg.153]    [Pg.394]   
See also in sourсe #XX -- [ Pg.3 , Pg.4 ]

See also in sourсe #XX -- [ Pg.51 ]




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An Unusual Case The Revival of Thalidomide

Angiogenesis, thalidomide effects

Anti-inflammatory action of thalidomide

Autistic features in maternal thalidomide

Barbiturates Thalidomide

Cancer, thalidomide

Capillary thalidomide

Chlorpromazine Thalidomide

Contergan - Thalidomide

Development thalidomide

Doxorubicin Thalidomide

Drug synthesis, thalidomide

Drugs thalidomide

Europe thalidomide

Hormonal) Thalidomide

Influence of Isomerism on Developmental Toxicity Thalidomide

Interferons Thalidomide

Isolation of Cereblon (CRBN) Using Thalidomide

Kevadon - Thalidomide

Leprosy, thalidomide

Lessons from thalidomide

Limb malformations, thalidomide

Look up the names of both individual drugs and their drug groups to access full information Thalidomide

Maternal thalidomide

Multiple myeloma thalidomide

Phocomelia, thalidomide

Pregnancy, thalidomide

Product liability thalidomide

S-Thalidomide

STEPS program Thalidomide Education

Side effects thalidomide

Synthetic chemicals Thalidomide

System for Thalidomide

System for Thalidomide Education

System for Thalidomide Education and

System for Thalidomide Education and Prescribing

System for Thalidomide Education and Prescribing Safety

Teratogen thalidomide

Teratogenesis thalidomide

Teratogenic effects of Thalidomide

Teratogenicity thalidomide-induced

Thalidomide

Thalidomide

Thalidomide 900 INDEX

Thalidomide A Bitter Lesson

Thalidomide Alcohol

Thalidomide Analogs

Thalidomide Ethanol

Thalidomide Kefauver-Harris

Thalidomide adverse drug effects

Thalidomide adverse effects

Thalidomide and Taxol Lessons Learned from Two Drugs

Thalidomide applications

Thalidomide as anti-inflammatory agent

Thalidomide birth defects caused

Thalidomide characteristics

Thalidomide chemistry

Thalidomide depressants)

Thalidomide disaster

Thalidomide enantiomers

Thalidomide episode

Thalidomide factors

Thalidomide hydrolysis products

Thalidomide impact

Thalidomide metabolites

Thalidomide pharmacokinetics

Thalidomide phocomelia with

Thalidomide preparative separation

Thalidomide regulation

Thalidomide revival

Thalidomide structure

Thalidomide synthesis

Thalidomide teratogenicity

Thalidomide toxicity testing

Thalidomide tragedy

Thalidomide, chirality

Thalidomide, removal

Thalidomide, teratogenic effects

Thalidomide, unknown effects

Thalidomide-induced birth

Thalidomide-induced birth defects

Thalidomide-related neuropathy

Thalomid - Thalidomide

Therapeutically thalidomide

Toxicity, thalidomide

United States thalidomide

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