Thalidomide preparative separation

Fig. 6.2 Chromatographic preparative separation ofthe enantiomers of thalidomide on a chiral polyacrylamide phase (from [18]).

A few years later, Blaschke designed purely synthetic chiral stationary phases obtained by emulsion polymerization of acrylamides prepared from amino acids [17]. These phases had been developed for preparative purposes and proved to be very efficient for the preparative resolution of various chiral drugs for which the enantiomers have been isolated for the first time. These earher applications include the separation of the enantiomers of the sadly well-known drug thalidomide (Fig. 6.2) [18],... 

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