Thiocarbamide derivatives

Aryl-substituted thiourea derivatives (thiocarbamide derivatives) [4] ... 

Tetrahydrocannabinol (= THC)-11-carboxylic acid 290 Tetrahydrocortiso 221 Tetrahydrocortisone 221 Tetrahydrosteroids 222 Tetrazolium salts, reduction 61 Thalidomide 45 -, hydrolysis products 45 Thiabendazole 307, 308 Thiamine 235, 236, 397 Thickening agents 179 Thin-layer chromatography, advantage 5 -, numbers of publications per year 6 Thiobarbiturates 45,66 Thiocarbamide derivatives 322 Thiocarbamides, N -ary I-N -benzenesulfo-nyl- 248,249 Thiochrome 395... 

The focus of the present chapter is upon thiocarbamide derivatives and in particular upon the persistence of N-H... S hydrogen bonding operating in their crystal structures. 

To obtain new antioxidants of combined action a number of nitrogen-containing compounds such as thiocarbamide derivatives with substituents of different character at nitrogen atom were synthesized. 

The reaction products of thiocarbamide derivatives with cumylperoxide radicals exhibit a secondary inhibiting effect. 

The kinetic parameters for reaction of the thiocarbamides with cumylperoxide radicals and cumyl hydroperoxide are also consistent with M-benzyl-A[ -(3-thiethanyl) thiocarbamide being faster in both oxidation chain termination (reacting with cumylperoxide radicals) and in catalytic decomposition of cumyl hydroperoxide. It was also shown that A -benzyl-V-(3-thiethanyl) thiocarbamide inhibits cumene autoxidation better than the other thiocarbamide derivatives when used in lower concentrations than the latter. 

Table 9.3 Kinetic parameters for the reaction of thiocarbamide derivatives with cumylperoxide radicals and cumyl hydroperoxide as well as the induction periods in cumyl autoxidation in presence of given antioxidants...

Although in the dry state carbon tetrachloride may be stored indefinitely in contact with some metal surfaces, its decomposition upon contact with water or on heating in air makes it desirable, if not always necessary, to add a smaH quantity of stabHizer to the commercial product. A number of compounds have been claimed to be effective stabHizers for carbon tetrachloride, eg, alkyl cyanamides such as diethyl cyanamide (39), 0.34—1% diphenylamine (40), ethyl acetate to protect copper (41), up to 1% ethyl cyanide (42), fatty acid derivatives to protect aluminum (43), hexamethylenetetramine (44), resins and amines (45), thiocarbamide (46), and a ureide, ie, guanidine (47). 

A number of substituted derivatives of 305 (cis, n = 1, 2 trans, n = 2), 306 cis or trans), 307, and 308 diendo and diexo) (R = Me, Et, Ph, substituted aryl) were prepared from the corresponding amino acids with isothiocyanate and acidic ring closure of the resulting thiocarbamide... 

Thiocarbamide 76.12 Chaotropic agent useful for membrane proteins will react with haloacetyl derivatives such as iodoacetamide protease inhibitor. 

The chemistry of sugar-derived thiocarbamic and dithiocarbamic esters was initially much less developed than that of the thiocarbamides already discussed, being limited to the condensation of reducing monosaccharides... 

In further studies of the synthesis of porphobilinogen and isoporphobilinogen, a-free pyrroles (prepared by Knorr type syntheses) were aminomethylated by the Tschemiak-Einhom reaction, for example, treatment with A -hydroxy-methylchloroacetamide in hot ethanolic hydrogen chloride. The resulting chloro-acetylamino derivatives (14) could be reduced catalytically to the acetylamino-methyl pyrroles (15). In related studies an acetylaminomethyl pyrrole (16b) was also prepared by treatment of 2,4-dimethylpyirole with acetyl thiocyanate followed by Raney nickel reduction of the intermediate acetyl thiocarbamide (16a). 

The alkyl derivatives of thiocarbamide can be divided into N-substituted thiocarbamide and S-substituted thiocarbamide. The expressions of N-substituted thiocarbamide and S-substituted thiocarbamide are given as follows ... 

Sulfur derivatives of purines and Thiocarbamide reaction Green or blue spots... 

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