Phenyramidol metabolites

Bromocresol green (3.8...5.4) aliphatic carboxylic acids[103,187 — 204] triiodobenzoic acid [205], derivatives of barbituric acid [206] amphetamine derivatives [207, 208] phenazones, morazone [209] alkaloids [91, 209] nephopam [210] phenyramidol metabolites [211] diethylalkylacetamide derivatives [212] zipeprol (Mirsol) [213] thalidomide and hydrolysis products [214] cyclohexylamine derivatives [215] herbicide residues [216]... 

Dicoumarol, warfarin and tromexan (67) have been shown to be metabolised by hepatic microsomal enzymes. These enzymes can be increased by phenobarbital and with the rapid metabolism of the anticoagulant its effect is reduced [451]. In contrast, phenyramidol inhibits the metabolism of coumarin and hence prolongs the duration of the anticoagulant response [445]. In the rat, the major metabolites of these compounds are 7-hydroxylated derivatives (68) [460— 462]. In man, besides the alteration of the ring [463], side-chain hydroxylation also occurs (69) in the rabbit, de-esterification proceeds rapidly (70) (see Figure 3.9). 

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