Thalidomide Ethanol

What do accutane, thalidomide, ethanol, radiation, and some viruses have in common toxicolog-ically ... 

Reproductive toxicant May damage fertility or the unborn child lA, IB Danger Known or presumed human reproductive toxicant DiethylstUbestrol, thalidomide, ethanol, organomercury compounds, lead, cocaine, l,2-dibromo-3-chloropropane... 

Nowhere are the effects of the permeability of the placental membrane more graphic than in the incidence of fetal alcohol syndrome (FAS) in the children of alcoholic mothers. FAS produces distinctive anatomical features and mental retardation. Ethanol is called a teratogen because it causes genetic malfunction. Recall that thalidomide was a teratogen. 

FIGURE 1 Chromatograms of the chiral resolution of thalidomide on the Prodigy C18 column using phosphate buffer (10 mM, pH 4.0)-ethanol (95 5, v/v) as the mobile phase containing /i-cydodextrin (20 mM) as the CMPA. (From Ref. 10.)... 

Dry gaseous ammonia can replace urea at the final high-temperature melt reaction. The reaction product requires multiple recrystallizations from 95% ethanol to furnish pure thalidomide (1) on a large scale. 

A,A-Dimethyl-4-aminoazobenzene 7,12-Dimethylbenzanthracene Ethanol Halothane A-Nitrosodimethylamine Vinyl chloride Thiocarbamides Thalidomide... 

Three crystalline modifications of thalidomide obtained by solvent recrystallization. (A) Form 1 obtained as bipyramids by slow crystallization of thalidomide in 1 1 dimethylformamide ethanol at room temperatnre. 

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