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Tetrahydrofuran activated

Liu B, Bazan GC (2007) Tetrahydrofuran activates fluorescence resonant energy transfer from a cationic conjugated polyelectrolyte to fluorescein-labeled DNA in aqueous media. Chem Asian J 2 499-504... [Pg.452]

Six-membered heterocycles are more resistant to an arene catalyzed lithiation than the corresponding five-membered ones. For instance, tetrahydropyran can not be cleaved under the reaction condition employed to open tetrahydrofuran (activation by BF3) ... [Pg.707]

Finally it should be noted that organolanthanides like dicyclopentadienyl(tert-butyl) lutetium tetrahydrofuranate activate carbon monoxide to form a new complex with an endiolate ligand (see section 2.7.1.), a reaction which should become quite important in synthetic organic chemistry (W.J. Evans et al., 1981d). A review dealing with his own work in this area appeared recently (W.J. Evans, 1983). [Pg.565]

Complete chirality transfer has been observed in the intramolecular allyla-tion of an alcohol with the activated allylic ester of 2,6-dichlorobenzoic acid 338 to give the 2-substituted tetrahydrofuran 339[208]. [Pg.336]

Optically active thiazoline-5-ones (203) can be obtained when cycliza-tion of an optically active N-thiobenzoyl amino acid is brought about by the use of dicyclohexyl carbodiimide in pure chloroform, dich-loromethane (455), or tetrahydrofuran (453. 456) (Scheme 104). [Pg.427]

Therapeutics. Compounds containing the furan or tetrahydrofuran ring are biologically active and are present in a number of pharmaceutical products. Eurfurjdamine [617-89-0] is an intermediate in the diuretic, furosemide. Tetrahydrofurfurylamine [4795-29-3] may also have pharmaceutical applications. 5-(E)imethyiaininomethyi)furfuryi alcohol [15433-79-17 is an intermediate in the preparation of ranitidine, which is used for treating ulcers. 2-Acet5dfuran [1192-62-7] prepared from acetic anhydride and furan is an intermediate in the synthesis of cefuroxime, a penicillin derivative. 2-Euroic acid is prepared by the oxidation of furfural. Both furoic acid [88-14-2] and furoyl chloride [527-69-5] are used as pharmaceutical intermediates. [Pg.83]

Acetyl chlotide is reduced by vatious organometaUic compounds, eg, LiAlH (18). / fZ-Butyl alcohol lessens the activity of LiAlH to form lithium tti-/-butoxyalumium hydtide [17476-04-9] C22H2gA102Li, which can convert acetyl chlotide to acetaldehyde [75-07-0] (19). Triphenyl tin hydtide also reduces acetyl chlotide (20). Acetyl chlotide in the presence of Pt(II) or Rh(I) complexes, can cleave tetrahydrofuran [109-99-9] C HgO, to form chlorobutyl acetate [13398-04-4] in about 72% yield (21). Although catalytic hydrogenation of acetyl chlotide in the Rosenmund reaction is not very satisfactory, it is catalyticaHy possible to reduce acetic anhydride to ethylidene diacetate [542-10-9] in the presence of acetyl chlotide over palladium complexes (22). Rhodium trichloride, methyl iodide, and ttiphenylphosphine combine into a complex that is active in reducing acetyl chlotide (23). [Pg.81]

Methyllithium. MethyUithium [917-54 ] CH Li, crystallizes from benzene or hexane solution giving cubic crystals that have a salt-hke constitution (128). Crystalline methyllithium molecules exist as tetrahedral tetramers (129). Solutions of methyllithium are less reactive than those of its higher homologues. Methyllithium is stable for at least six months in diethyl ether at room temperature. A one-molar solution of methyllithium in tetrahydrofuran (14 wt %) and cumene (83 wt %) containing 0.08 M dimethyknagnesium as stabilizer loses only 0.008% of its activity per day at 15°C and is nonpyrophoric (117). [Pg.229]

A variant of the Wurtz reaction is the preparation of tetrabutyltin from activated magnesium chips, butyl chloride, and stannic chloride in a hydrocarbon mixture. Only a small amount of tetrahydrofuran is required for the reaction to proceed in high yield (86). [Pg.68]

Oxygen has also been shown to insert into butadiene over a VPO catalyst, producing furan [110-00-9] (94). Under electrochemical conditions butadiene and oxygen react at 100°C and 0.3 amps and 0.43 volts producing tetrahydrofuran [109-99-9]. The selectivity to THF was 90% at 18% conversion (95). THF can also be made via direct catalytic oxidation of butadiene with oxygen. Active catalysts are based on Pd in conjunction with polyacids (96), Se, Te, and Sb compounds in the presence of CU2CI2, LiCl2 (97), or Bi—Mo (98). [Pg.343]

Casuscelli and colleagues (95T8605) reported the conversion of the 3-carboxy-butyl-substituted isoxazolidines 60 (R = alkyl, CH2OH R = H, Me) into 3-me-thylamino-2(5// )-furanones 61 by the activity of sodium hydride in tetrahydrofuran... [Pg.116]

D) Preparation of 4-[1 -Methyl-Piperidyl-(4 )]-9,10-Dihydro-4H-Benzol4,5]Cyciohepta[1,2-b] Thiophen-(4)-ol 0.94 g of magnesium filings which have been activated with iodine are covered with a layer of absolute tetrahydrofuran and etched with a few drops of ethylene bromide. A solution of 5.0 g of 1-methyl-4-chloropiperidine in 5 ml of tetrahydrofuran is then added dropwise and boiling then effected for a further hour under reflux. After cooling to room temperature, the solution of 4.5 g of 9,lO-dihydro-4H-benzo[4,5] cyclohepta[1,2-b] thio-phen-(4)-one in 5 ml of tetrahydrofuran is added dropwise. [Pg.1264]

Cationic polymerization of tetrahydrofuran with the or bis(3,5-di-bromomethyl) benzoyl peroxide and AgPp6 pairs of 4,4 -bromomethyl benzoyl peroxide and AgPp6 yield active poly-THP having peroxide group in the main... [Pg.727]

Thermoplastic resins, self-reinforced, 26 Thermoplastics, preparation of, 257-258 Thermoplastic step-growth polymers, 3 Thermosetting polyester resins, 29-31 Thermosetting resins, 3-4, 19 Thermotropic compounds, 49 THF. See Tetrahydrofuran (THF) Thiobisphenol S (TBPS), 364 Thionyl chloride, 80 activation of, 111 3,3 -linked polymers, 480 Tin-amine coordination complex, 234 Tin compounds, 86, 232-233... [Pg.603]

Cationic polymerization of ethylene oxide is accompanied by depolymerization and oligomerization. It has been reported that ethylene oxide polymerized cation-ically with the living dication of tetrahydrofuran and a surface active material was obtained290. ... [Pg.26]

Aqueous Diels-Alder reaction has also been applied at the industrial level. 2,2,5-Trisubstituted tetrahydrofurans 21 are a class of active azole antifungals. Workers at Schering-Plough [21] developed a synthetic approach based on a Diels-Alder reaction between 2-arylfurans 22 and ethyl acetylenedicarboxylate (Scheme 6.9). Under thermal conditions the reaction gave a low yield of... [Pg.260]

Aqueous solutions are not suitable solvents for esterifications and transesterifications, and these reactions are carried out in organic solvents of low polarity [9-12]. However, enzymes are surrounded by a hydration shell or bound water that is required for the retention of structure and catalytic activity [13]. Polar hydrophilic solvents such as DMF, DMSO, acetone, and alcohols (log P<0, where P is the partition coefficient between octanol and water) are incompatible and lead to rapid denaturation. Common solvents for esterifications and transesterifications include alkanes (hexane/log P=3.5), aromatics (toluene/2.5, benzene/2), haloalkanes (CHCI3/2, CH2CI2/I.4), and ethers (diisopropyl ether/1.9, terf-butylmethyl ether/ 0.94, diethyl ether/0.85). Exceptionally stable enzymes such as Candida antarctica lipase B (CAL-B) have been used in more polar solvents (tetrahydrofuran/0.49, acetonitrile/—0.33). Room-temperature ionic liquids [14—17] and supercritical fluids [18] are also good media for a wide range of biotransformations. [Pg.134]


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See also in sourсe #XX -- [ Pg.250 ]




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