Genetic Tests

Diagnosis of CF is based on two separate elevated sweat chloride concentrations of greater than or equal to 60 mEq/L (or mmol/L) obtained through pilocarpine iontophoresis (referred to as the sweat test ). Genetic testing (CFTR mutation analysis) may be performed to confirm the diagnosis, screen in utero, or detect carrier status. More than 70% of diagnoses are made by 12 months of age and almost all are made by age 12. 

United States Department of Agriculture. USDA strengthens 2003 permit conditions for field testing genetically engineered plants. Available from http //www.a phis.usda.gov/lpa/news/ 2003/03/ gepermits brs.html... 

American College of Medical Genetics (ACMG), "Position Statement on Gene Patents and Accessibility of Gene Testing," Genet Aw. Med., 1, 237 (1999). 

Once a person decides to proceed with genetic testing, a medical geneticist, primary care doctor, specialist, or nurse practitioner can order the test. Genetic testing is often done as part of a genetic consultation. 

Lindow requested government permission to test genetically engineered bacteria to control frost damage to potatoes and strawberries. 

On the basis of maternal hair concentration, the third study (conducted in the Seychelles) did not find any association between prenatal methylmercury exposure and adverse neuro-psychologic effects (Myers et al. 2003). Reasons for the discrepancies are not known but have been suggested to include differences in the child s age at testing, genetic susceptibilities of the populations, patterns of exposure (episodic vs continuous), and coexposure to polychlorinated biphenyls in the Faroes but not Seychelles populations (Rice et al. 2003). 

Richards CS, Bradley LA, Amos J, Allitto B, Grody WW, Maddalena A, McGinnis MJ, Prior TW, Popovich BW, Watson MS, Palomaki GE. Standards and guidelines for CFTR mutation testing. Genet Med 2002 4 379-391. 

Clerget-Darpoux F, Babron MC, Prum B, Lathrop GM, Deschamps I, Hors J. A new method to test genetic models in HLA associated diseases the MASC method. Ann Hum Genet 1988 52 247-258. 

Peptide Class Safety Pharmacology VChronic Toxicity Carcinogenicity Testing Genetic Toxicity Method of Manufacture Approval Date... 

Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA. American College of Medical Genetics consensus statement on factor V Leiden mutation testing. Genet Med 2001 3 139-48. 

Restriction of experimental toxicant testing to nonhuman animals Models of appropriate developmental stage and age can be tested Genetic polymorphisms... 

---