Genetic toxicity testing predictive ability

Although the use of simple test systems to predict genetic effects in whole mammals is desirable, comparison of dosages in submammalian systems with human exposure is extremely complex. The nature of the exposure, cellular toxicity, and units of measurement differ markedly from one type of organism to another. Molecular dosimetry that measures adducts in DNA is promising,1-3 237-239 jjUt the ability to relate exposures in short-term test systems, including mammalian cell cultures, to human risks is primitive. There are much better grounds for qualitative than for quantitative extrapolation. 

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