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Inhalation Exposure. Only one inhalation MRL, a chronic MRL for //-hexane, is available for this combined fraction this is listed in Table 6-8. //-Hexane produces a characteristic peripheral nephropathy in humans and animals the chronic MRL is based on this effect in humans. Commercial hexane, which contains //-hexane plus other C6 branched chain and cyclic alkanes (see Table 6-8), also has been shown to cause this effect in animals, due to its content of //-hexane (IRDC 1981) (see Section 6.2.4.1). The non n-hexane portion of the mixture does not. In addition, the non //-hexane constituents of this combined fraction do not appear to cause peripheral neuropathy when tested singly although, like //-hexane, they do cause neurological effects (depression of the central nervous system). //-Hexane and commercial hexane are respiratory irritants. Commercial hexane has undergone extensive recent testing as part of an EPA Test Rule under TSCA Section 4. However, until the database for commercial hexane can be more fully evaluated, the chronic MRL for //-hexane has been determined to be the most appropriate surrogate for a health guidance value for this fraction. [Pg.193]

The main justification for diesel fuel desulfurization is related to particulate emissions which are subject to very strict rules. Part of the sulfur is transformed first into SO3, then into hydrated sulfuric acid on the filter designed to collect the particulates. Figure 5.21 gives an estimate of the variation of the particulate weights as a function of sulfur content of diesel fuel for heavy vehicles. The effect is greater when the test cycle contains more high temperature operating phases which favor the transformation of SO2 to SO3. This is particularly noticeable in the standard cycle used in Europe (ECE R49). [Pg.254]

This rule is justified by the need to limit the benzene emissions from evaporation (Tims, 1983) Figure 5.25 shows that emissions increase linearly with the benzene content of the fuel. It is noteworthy that current legislation limits the measured evaporation to 2 g per test conducted in accordance with a standard procedure (Sealed Housing for Evaporative Determination, or SHED). Yet for a fuel containing 5% benzene, an evaporation of 0.7 g benzene /test is observed. [Pg.258]

Tests by Roe et al. [63] with unidirectional jute fiber-reinforced UP resins show a linear relationship (analogous to the linear mixing rule) between the volume content of fiber and Young s modulus and tensile strength of the composite over a range of fiber content of 0-60%. Similar results are attained for the work of fracture and for the interlaminate shear strength (Fig. 20). Chawla et al. [64] found similar results for the flexural properties of jute fiber-UP composites. [Pg.805]

Since the 1993 court decision against Barr Laboratories, 5 tjjg elimination of outliers has taken on a decidedly legal aspect in the U.S. (any non-U.S. company that wishes to export pharmaceuticals or preciwsor products to the U.S. market must adhere to this decision concerning out-of-specifica-tion results, too) the relevant section states that ... An alternative means to invalidate an individual OOS result... is the (outlier test). The court placed specific restrictions on the use of this test. (1) Firms cannot frequently reject results on this basis, (2) The USP standards govern its use in specific areas, (3) The test cannot be used for chemical testing results. ... A footnote explicitly refers only to a content uniformity test, 5 but it appears that the rule must be similarly interpreted for all other forms of inherently precise physicochemical methods. For a possible interpretation, see Section 4.24. [Pg.61]

The performance curve presents graphically the relationship between the probability of obtaining positive results PPRy i.e. x > xLSp on the one hand and the content x within a region around the limit of discrimination xDIS on the other. For its construction there must be carried out a larger number of tests (n > 30) with samples of well-known content (as a rule realized by doped blank samples). As a result, curves such as shown in Fig. 4.10 will be obtained, where Fig. 4.10a shows the ideal shape that can only be imagined theoretically if infinitely exact decisions, corresponding to measured values characterized by an infinitely small confidence interval, exist. [Pg.115]

Instructions on how to prepare samples for thermal analyses can be given only very generally since the variety and complexity of the problems involved makes it impossible to specify strict rules of procedure. In carrying out series of tests on any particular material, it is advisable to make this up in sufficient quantity and also to test it by other analytical methods such as X-ray and IR. All samples should be as far as possible homogeneous. Sample conditioning, i.e. adjustment to a predetermined degree of moisture content, may be carried out either before or after samples are weighed and loaded on the thermobalance. [Pg.87]

Various dry powder attributes are assessed at release and on stability. These include physieal eharaeteristies sueh as appearance, content uniformity, delivered dose uniformity, and partiele size distribution. Chemieal attributes that may be assessed include drug eontent, purity, and identity, as well as the water content. Dry powders may also undergo mieroseopie evaluation for foreign particulate matter, unusual agglomeration, and partiele size. Mierobial limits should also be examined, including the total aerobie, yeast, and mold eounts. The presence of specific pathogens should be ruled out. The dry powders may be dissolved to test for pH. [Pg.111]

Quantitative methodology uses large or relatively large samples of subjects (as a rule students) and tests or questionnaires to which the subjects answer. Results are treated by statistical analysis, by means of a variety of parametric methods (when we have continuous data at the interval or at the ratio scale) or nonparametric methods (when we have categorical data at the nominal or at the ordinal scale) (30). Data are usually treated by standard commercial statistical packages. Tests and questionnaires have to satisfy the criteria for content and construct validity (this is analogous to lack of systematic errors in measurement), and for reliability (this controls for random errors) (31). [Pg.79]

The alcohol content averaged 15.09%, or 0.09% above target. Individual batches met specification in every instance. The control chart (Fig. 12) was unremarkable in terms of trends or tests for pattern instability. Batch 3 is slightly below the process average, effectively ruling out overaddition of alcohol as a factor in the low specific gravity previously observed. [Pg.103]

Test results at 25°C and 90°C have been interpreted at Pennsylvania State University as follows. The higher the purity of the Zr02, the more likely it is to behave well as a pH sensor. Exceptions to this rule are titanium, which is beneficial for thermal shock resistance, and yttria, which is necessary for polymorphic stabilization. The optimum Y20, content was investigated by testing Zr02 tubes with Y203 contents of 4, 6, 8, 10, and 12 mol%. [Pg.208]

The animals should be tested with inhalation equipment designed to sustain a dynamic air flow of 12 to 15 air changes per hour, and to ensure an adequate oxygen content of 19% and an evenly distributed atmosphere. Whenever a chamber is used, its design should minimize crowding of test animals and maximize their exposure to the chemical. As a general rule, to ensure stability of the chamber atmosphere, the total volume of the test animals should not exceed 5% of the test chamber volume. Alternatively, oronasal, head only, or whole-body individual exposure chambers may be used. [Pg.477]

This and many similar examples prove that the inborn mind of a child submits any new term to an unconscious acceptability test , and what is actually scrutinised first is not the content of the new term (the information that it is delivering) but its ability to play the rules of the game. What matters, before anything else, are not the individual characteristics of the new term but its group properties. [Pg.237]


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