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Target-based

Safety and environmental objectives and targets based on the results of the safety and environmental assessment... [Pg.150]

However, the target validation step is unique to target-based drug discovery. [Pg.177]

A major approach to discovery is the target-based approach, whereby a single biological target is... [Pg.193]

Recombinant systems are the main tools of target-based approaches. These can be manipulated, but information is lacking for complete modeling of therapeutic systems. [Pg.195]

Central tendency, 226-227 Chemical genomics, 178 Chemical tools, in target-based drug discovery, 178-179 Chemokine C receptor type 1, 133 Chemokine receptors, 6, 44, 53, 129, 132, 177... [Pg.294]

Tang Herbal, 147 Target-based drug discovery biological targets, 180-184 chemical end point in, 180 chemical tools, 178-179 definition of, 5 description of, 175-177 linear approach, 176 orphan receptors, 180 preclinical process in, 176-177 random variation in gene expression, 178... [Pg.299]

Barton and coworkers have shown that proteins can in fact modulate the DNA electron transfer [168]. Methyltransferases are enzymes that recognize distinct DNA sequences, e.g., 5 -G CGC-3, and effect methylation by extrading the target base cytosine ( C) completely out of the DNA duplex while the remainder of the double helix is left intact. The methyltransferase Hha 1-DNA complex is a well-characterized example, revealing that the structure of the DNA is significantly but locally distorted [169,170]. In a recent study, Raj ski et al. used DNA duplex 20 containing the M.Hha I binding site between two oxidizable 5 -GG-3 sites [168] (Fig. 20). The duplex contains a complementary strand, selectively 5 -modified with a Rh intercalator that can function as a photooxidant. Upon... [Pg.421]

This protocol was extended to other inorganic colloids (e.g., ZnS, PbS), and it was pointed out that such extension paves the way to an electrochemical coding technology for the simultaneous detection of multiple DNA targets based on nanocrystal tags with diverse redox potentials [148]. [Pg.341]

Biology related includes target-disease linkage, clinical efficacy, and target-based toxicity (exaggerated pharmacology)... [Pg.394]


See other pages where Target-based is mentioned: [Pg.218]    [Pg.58]    [Pg.275]    [Pg.184]    [Pg.5]    [Pg.175]    [Pg.175]    [Pg.175]    [Pg.175]    [Pg.176]    [Pg.177]    [Pg.177]    [Pg.178]    [Pg.179]    [Pg.179]    [Pg.180]    [Pg.181]    [Pg.183]    [Pg.184]    [Pg.184]    [Pg.184]    [Pg.186]    [Pg.190]    [Pg.295]    [Pg.585]    [Pg.893]    [Pg.321]    [Pg.145]    [Pg.157]    [Pg.937]    [Pg.1]    [Pg.18]    [Pg.66]    [Pg.4]    [Pg.208]    [Pg.615]    [Pg.156]    [Pg.170]    [Pg.56]    [Pg.346]   
See also in sourсe #XX -- [ Pg.157 ]




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A Typical Cellular Targeting Strategy Using 1-D NS-Based Nanostructures

Active targeting pharmaceuticals based

Alignment target-based

Biologicals Are the Low Hanging Fruit of Genomics-Based Target Discovery

Chemicals health-based targets

Community-based targeting

Customer base target markets

Drug, drugs target-based

Effects-based targeting/operations

Electrochemical Aptasensors Based on Target-Induced Aptamer Displacement

Epigenetic Targets in Drug Discovery Cell-Based Assays for HDAC Inhibitor Hit Validation

Health-based targets

Herpes simplex virus type 1 thymidine kinase a target for gene-therapy based anticancer drugs

Identification and Validation of Drug Targets Using Activity-based Probes

Image-based target prediction

Knowledge-based Combinatorial Library Design Strategies within Homogenous Target Subfamilies

Library design target structure-based

Ligand-based Targeting of Disease From Antibodies to Small Organic (Synthetic) Ligands

Ligand-based Template Design for GPCR-targeted Libraries

Ligand-based targeting

Malaria target-based approaches

Passive targeting pharmaceuticals based

Polymer-based targeting

Protein target-based virtual screening

Receptor-based drug targeting

Scaffold target-based

Structure-Based Lead Identification for Epigenetic Targets

Structure-based drug design future targets

Structure-based lead optimization application to specific targets

Target cell-based screening

Target family-based

Target site-based resistance

Target-Based Approaches

Target-Based Virtual Screening on Small-Molecule Protein Binding Sites

Target-Based antimicrobial drug discovery

Target-based biochemical assays

Target-based costing

Target-based drug discovery

Target-based research

Target-based screening

Targeting CD44-Expressing Tumours In Vivo with Hyaluronic Acid-based Nanoparticles

Virtual target-based

Virtual target-based screening

Water quality health-based targets

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