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Receptor orphan

Orphan receptor, a gene product that is predicted to be a receptor through structure and spontaneous interaction with G-proteins but for which there is no known endogenous ligand or physiological function. [Pg.281]

One-way analysis of variance, 229-230, 230f—231f Operational model derivation of, 54-55 description of, 45—47, 46f function for variable slope, 55 for inverse agonists, 221 of agonism, 47f orthosteric antagonism, 222 partial agonists with, 124, 220-221 Opium, 147 Orphan receptors, 180 Orthosteric antagonism... [Pg.297]

Tang Herbal, 147 Target-based drug discovery biological targets, 180-184 chemical end point in, 180 chemical tools, 178-179 definition of, 5 description of, 175-177 linear approach, 176 orphan receptors, 180 preclinical process in, 176-177 random variation in gene expression, 178... [Pg.299]

High-throughput Screening Combinatorial Chemistry Orphan Receptors... [Pg.447]

Peroxisome Proliferator-Activated Receptors (PPARs) P450 Mono-oxygenase System Nuclear Receptors Orphan Receptors... [Pg.914]

There are now many examples of novel peptide transmitter systems that have been identified through orphan receptor ligand screening and greatly impacted the basic understanding of human physiology. Prime examples for the discovery of novel transmitter with therapeutic implications are the neuropeptides orphaninFQ/... [Pg.917]

A 17 amino acid long peptide sequentially related to opioid peptides in particular dynorphin A. OFQ/N is inactive at the 5, k, and p opioid receptors, but binds to its own NOP receptor (formerly ORL-1, for opioid receptor like-1). In contrast to opioid peptides, OFQ/N has no direct analgesic properties. OFQ/N is the first example for the discovery of a novel neurotransmitter from tissue extracts by using an orphan receptor as bait. Centrally administered in rodents, OFQ/N exerts anxiolytic properties. OFQ/N agonists and antagonists... [Pg.917]

Synthetic molecule or peptide that is able to activate an orphan receptor but differs in chemical structure from the natural endogenous ligand... [Pg.1168]

See other pages where Receptor orphan is mentioned: [Pg.518]    [Pg.180]    [Pg.180]    [Pg.181]    [Pg.201]    [Pg.536]    [Pg.633]    [Pg.894]    [Pg.894]    [Pg.898]    [Pg.898]    [Pg.898]    [Pg.902]    [Pg.903]    [Pg.903]    [Pg.914]    [Pg.914]    [Pg.914]    [Pg.914]    [Pg.914]    [Pg.914]    [Pg.914]    [Pg.915]    [Pg.915]    [Pg.915]    [Pg.916]    [Pg.916]    [Pg.917]    [Pg.917]    [Pg.917]    [Pg.917]    [Pg.917]    [Pg.918]    [Pg.939]    [Pg.939]    [Pg.939]    [Pg.1071]    [Pg.1076]    [Pg.1079]    [Pg.1127]    [Pg.1168]    [Pg.1195]    [Pg.1218]   
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Orphan

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Orphan chemokine receptor

Orphan nuclear receptors

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Orphan opioid receptor

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Orphan receptors drug discovery using

Orphan receptors function

Retinoic acid receptor-related orphan

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