Tablet coats sugar

The traditional tablet coating is a sugar coat applied in stages. First the tablet surface is sealed... 

Lubricants are used in tablet preparation and include magnesium stearate, stearic acid and polyethylene glycol. They only comprise at most 1-2% of the tablet bulk so that their potential to interfere is slight, particularly since their chromophores are weak. The fatty acid lubricants can often be observed if analysis of a tablet extract is carried out by GC-FID. Tablet coatings are often based on modified sugar polymers such as hydroxypropylmethylcellulose. These coatings are used at about 3% of the tablet bulk, are water soluble and do not absorb UV light. 

Tablet coating can occur by different techniques (e.g., sugar, film, or compression). Film coating has been the most common technique over recent years and will be the focus of this section.

Sucrose syrups are used as tablet-coating agents at concentrations between 50% and 67% w/w. With higher concentrations, partial inversion of sucrose occurs, which makes sugar coating difficult. 

Sugar coatings are particularly susceptible to cracking when they are applied to large batches of tablet cores that are dried rapidly. As most active substances are hydrophobic, copovidone is useful as an additive to prevent the tablet coating cracking away from the tablet core during manufacture. 

The traditional tablet coating is a sugar coat applied in stages. First the tablet surface is sealed to prevent the ingress of water, then a subcoat of an aqueous polymeric or sucrose solution is added to smooth the tablet s surface. This can be repeated until the desired size and shape is achieved. 

Tablet Coating. Many tablet dosage forms are coated to mask or minimize the unpleasant taste or odor of certain drugs, to protect the drug against decomposition, and to enhance the appearance. Traditionally, tablets were coated with sucrose by repeated application of a syrup followed by forced drying in hot air. The sugar...

Uses Nutritive sweetener for foods (diabetic and dietetic foods) and pharmaceuticals (liqs., tablets, coatings, lozenges) dietary supplement sugar substitute humectant, stabilizer, emulsifier, thickener in foods humectant, emollient in cosmetics, creams/milks plaque formation inhibitor in dental care prods. 

Enteric coating is also used for repeat-action tablets, which contain an enteric-coated core tablet and a sugar or film-coated second dose, permitting the adininistration of two doses simultaneously. The core dose is released several hours after the initial, outer dose. 

Sugar coating is time-consuming, requires skilled operators, and increases the tablet weight, sometimes to twice that of the uncoated core. 

Erodings of Slow-Releasing Core Tablets. The sustained-dose portion of a dmg is granulated with hydrophobic materials such as waxes, fatty acids, or fatty alcohols and compressed into a core. The initial dose is added to the core by a modified sugar coating process or by compression coating. Thus, a tablet within a tablet is created. The core erodes slowly to release the active ingredient. 

Baugh and co-workers exposed solutions of phenylbutazone to the light of a projector lamp in the presence of typical dyes used to colour sugar-coated tablets. Erythrosine sodium photosensitized decomposition of the drug via, it was suggested, singlet oxygen [134]. 

The flow-through cell is applicable not only for the determination of the dissolution rate of tablets and sugar-coated tablets, but has also been applied to suppositories, soft-gelatin capsules, semisolids, powders, granules, and implants. A small volume cell containing the sample solution is subjected to a continuous stream of dissolution media. The dissolution... 

Coat Physical protection of tablet Sugar, methylceUulose, cellulose acetate... 

Sugar-coated products have been marketed that contain KCl in a wax matrix (Slow-K and Kaon-Ct) and are purportedly slow- and controlled-release preparations. Available evidence indicates that these slow-release forms of KCl are occasionally capable of causing local tissue damage and therefore prol5ably should be used with caution for K+ supplementation. Solutions of potassium gluconate, like the tablets, also have been associated with intestinal ulceration. Microencapsulated KCl preparations Micro-K, K-Dur) that are neither enteric coated nor contained within a wax matrix appear to be superior to the wax matrix formulation. 

In contrast, oral administration of a willow bark extract showed a low bioavailability of salicin (98). After ingestion of commercial sugar-coated tablets containing willow bark extract corresponding to a total amount of 54.9mg (0.192mmol) salicin, the serum of 12 volunteers showed a peak concentration of only 0.13 pg/mL salicylic acid this is only 5% of the serum... 

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