Tablet calculation

The ultraviolet assay of tablets which contain only Isopropamlde as the active ingredient Is the most direct method employed (lif). Twenty tablets (5 mg/ tablet) are placed In a 250 ml. volumetric flask, disintegrated In about 150 ml. of water, and diluted to volume with water. The solution is filtered through Whatman No. 1 filter paper (l5),50.0 ml. of the filtrate percolated through an anion exchange column (16), and the column rinsed thoroughly with water. All eluates are collected in a 100 ml. volumetric flask and diluted to volume with water. The ultraviolet absorption spectrum of this solution Is compared with that of a known standard of Isopropamlde under the same spectrophotometric conditions and the assay value per tablet calculated. 

TABLETS Calculated pre-e q)onential values for ozone reaction with dihydroxy benzenes. 

Tablet Calculated equilibrium bond distances [A] of the dihalogens as obtained with different methods applying the aug-cc-pVTZ basis set [35]...

The vitamin B12 content of a multivitamin tablet is determined by dissolving ten tablets in water. The dissolved tablets are transferred to a 100-mL volumetric flask and diluted to volume. A 50.00-mL portion is removed and treated with 0.500 mg of radioactive vitamin B12 having an activity of 572 cpm. After homogenization, the vitamin B12 in the sample is isolated and purified, producing 18.6 mg with an activity of 361 cpm. Calculate the average concentration of vitamin B12 in the tablet (in milligrams per tablet). 

Figure 4.39. Variability of back calculated concentrations Concbc- For each concentration range five calibration points were measured, over which a separate regression was run (not shown). Placebo tablets were spiked to the same concentrations and measured in triplicate (short horizontal lines gray trend lines in background). Ten repeat determinations of actual product (vertical bars = Mean + SD) were done. The bold lines pertain to compound A in all concentration ranges, the thin lines to compound B (middle concentration range only).

Example 61 The raw data, given as %-of-nominal values with one decimal place, are found in Table 4.37 For each group of 10 values the mean and the standard deviation were calculated. Using these, the t-values for the differences L - mean, with L = 75, 85, 115, resp. 125% were determined they are all above 2.9, indicating low risk. The corresponding CP-values were calculated the differences ACP75-85 and ACP 15-125 were added and multiplied by 100 to obtain the approximate risk, in %, of finding a result between the inner and the outer limits. For a content uniformity test with n = 10 tablets, a risk of 0.003872% translates into a deviant result once every 20-25 trials, or, with six CU runs per batch, every third or fourth batch. 

Figure 4.51. Distribution of experimental data. Six experimental formulations (strengths 1, 2, resp. 3 for formulations A, respectively B) were tested for cumulative release at five sampling times (10, 20, 30, 45, respectively 60 min.). Twelve tablets of each formulation were tested, for a total of 347 measurements (13 data points were lost to equipment malfunction and handling errors). The group means were normalized to 100% and the distribution of all points was calculated (bin width 0.5%, her depicted as a trace). The central portion is well represented by a combination of two Gaussian distributions centered on = 100, one that represents the majority of points, see Fig. 4.52, and another that is essentially due to the 10-minute data for formulation B. The data point marked with an arrow and the asymmetry must be ignored if a reasonable model is to be fit. There is room for some variation of the coefficients, as is demonstrated by the two representative curves (gray coefficients in parentheses, h = peak height, s = SD), that all yield very similar GOF-figures. (See Table 3.4.)...

Levothyroxine (Synthroid , Levoxyl , Unithroid ), other brands, and generics Synthetic LT4 25, 50, 75, 88, 100, 112, 125, 137, 150, 1 75, 200, and 300 meg tablets 500 meg vial for injection 60 meg Gold standard for treating hypothyroidism products not therapeutically equivalent full replacement dose 1-1.6 meg/kg per day when switching from animal product, lower calculated daily dose by 25-50 meg intravenous form rarely needed... 

Calcium supplements are available in a variety of calcium salts and dosage forms. Calcium requirements are listed in terms of elemental calcium. However, many product labels list calcium content in the salt form, so the percent of elemental calcium must be known to calculate the elemental calcium content per tablet. 

Often it is unnecessary to calculate an exact value for an absorption rate constant. For example, when several oral tablets containing the same drug substance are all found to be completely absorbed, it may be sufficient to merely determine if the absorption rates are similar to conclude that the products would be therapeutically equivalent. In another instance, it would be possible to choose between an elixir and a sustained-release tablet for a specific therapeutic need without assigning accurate numbers to the absorption rate constant for the two dosage forms. 

Thus, if one plots logf i7) vs. time, one only needs to calculate the slope of the line so plotted to determine the plastic flow, k. Materials with higher values of k (i.e., more plastic flow) tend to form stronger tablets than those with low k values. 

Several all-in-one tablet testers are currently available that measure weight, thickness, diameter, and hardness of tablets. In addition these instruments provide digital storage and calculation of statistical parameters and allow for rapid feedback during the tableting process so that the tableting equipment can be adjusted accordingly with minimal downtime. ... 

Most pharmacopoeias include a simple weight test on a specified number of tablets that are weighed individually. The arithmetic mean weight and relative standard deviation (i.e., mean divided by standard deviation) of these tablets is then calculated. Only a specified number of test tablets may lie outside the prescribed limits. These specifications vary depending upon the type of tablet and amount of active present. 

Content uniformity is a USP test is designed to establish the homogeneity of a batch. Ten tablets are assayed individually after which the arithmetic mean and relative standard deviation (RSD) are calculated. USP criteria are met if the content uniformity lies within 85-115% of the label claim and the RSD is not greater than 6%. Provision is included in the compendium for additional testing if one or more units fail to meet the standards. 

From a test of the tablet s flexure, tensile strength (oy) is calculated from the following equation ... 

Bindschaedler and Gurny [12] published an adaptation of the simplex technique to a TI-59 calculator and applied it successfully to a direct compression tablet of acetaminophen (paracetamol). Janeczek [13] applied the approach to a liquid system (a pharmaceutical solution) and was able to optimize physical stability. In a later article, again related to analytical techniques, Deming points out that when complete knowledge of the response is not initially available, the simplex method is probably the most appropriate type [14]. Although not presented here, there are sets of rules for the selection of the sequential vertices in the procedure, and the reader planning to carry out this type of procedure should consult appropriate references. 

Using the relative response factors that you calculated in the last Section, correct each peak area by dividing by the appropriate response factor. For each injection, calculate the amount Of aspirin and caffeine present, expressing the results as mg per tablet. 

From the uv absorption spectra, a suitable wavelength is found for the simultaneous detection of aspirin, phenacetin and caffeine. Using phenacetin as internal standard, response factors are calculated for aspirin and caffeine and the results are used for the quantitative determination of aspirin and caffeine in an analgesic tablet. 

Calculate the total moles of HCI that were added to the tablet. 

Calculate the mmoles of NaAl(0H)2C03 in one antacid tablet. 

Calculate the mmoles of HC1 that can be neutralized by the antacid tablet. 

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