T-cell differentiation

B cells also have impact on T-cell differentiation. B-cell antigen presentation plays an important role at promoting Th2 responses and pathophysiology during allergic disorders. It has been shown that B-cell -/- mice and in mice selectively deficient in MHCII on B cells had decreased Th2 cytokines IL-4 and IL-5 [152]. Also in another study it has been reported that B-cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce Th2 cytokines IL-5 and IL-13 [42]. 

Ray P. Krishnamoorthy N. Ray A Emerging functions of c-kit and its ligand stem cell factor in dendritic cells regulators of T cell differentiation. Cell Cycle 2008 7 2826-2832. 

Luther SA, Cyster IG (2001) Chemokines as regulators of T cell differentiation. Nat Immunol 2 102-107... 

Key Words Chemokines lymphocyte development T-cell differentiation cell trafficking memory thymus bone marrow. 

Berkowitz RD, Beckerman KP, Schall TJ, McCune JM. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. J Immunol 1998 161 3702-3710. 

Song K, Rabin RL, Hill BJ, et al. Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans. Proc Nad Acad Sci U S A 2005 102 7916-791621. 

Rabin RL, Alston MA, Sircus JC, et al. CXCR3 is induced early on the pathway of CD4+ T cell differentiation and bridges central and peripheral functions. J Immunol 2003 171 2812-2824. 

Tai X, Cowan M, Feigenbaum L, Singer A CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin-2. Nat Immunol 2005 6 152-162. 

Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007 445 771-775. 

Mucida D, Park Y, Kim G, Turovskaya 0, Scott I, Kronenberg M, Cheroutre H Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007 317 256-260. 

Tregs and effector T cells, so that naive CD4-F T cells differentiate into Foxp3-F Tregs in the presence of TGF-(3 or into Thl7 cells in the presence of TGF-(3 and IL-6. Thus T-cell activation in the... 

Kobayashi, T., Lijima, K., Mitamura, T., Toriizuka, K., Cyong, J., andNagasawa, H. 1996. Effects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4/CD8 ratio in high mammary tumor strain of SHN retired mice. Anticancer Drugs 7, 195-198. 

T cell development, similar to B cell ontogeny, can also be divided into stages based on antigen expression (Table 4) extrathymic precursor, prothymocyte, immature thymocyte, common thymocyte, mature thymocyte, and mature peripheral T cell. However, while the early stages of T cell development are well characterized, the later stages of T cell differentiation, that is, those of the mature peripheral T cell, have not been fully delineated (C3, F12, H13, K15, K16, K20, R6-R8,V3, V4). Furthermore, although natural killer (NK) cells are closely related to T cells (S21), the stages of differentiation of this lymphoid cell population are not completely understood. 

T Cell Differentiation Immunophenotypic Profiles of Thymocytes and Thymocyte Precursors... 

M24. Mirro, J., Jr., Kitchingman, G., Behm, F. G., Murphy, S. B., and Goorha, R. M., T cell differentiation stages identified by molecular and immunologic analysis of the T cell receptor complex in childhood lymphoblastic leukemia. Blood 69,908-912 (1987). 

V4. van Dongen, J. J., Quertermous, T., Bartram, C. R., Gold, D. P., Wolvers-Tettero, I. L., Comans-Bitter, W. M., Hooijkaas, H., Adriaansen, H. J., de Klein, A., Raghavachar, A., et al. T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias (T-ALL) at DNA, RNA, and cell membrane level. J. Immunol. 138, 1260-1269 (1987). 

A. Monoclonal Antibodies to T-Cell Differentiation and Function-Associated... 

Ritchie AJ, Jansson A, Stallberg J, Nilsson P, Lysaght P, Cooley MA (2005) The Pseudomonas aeruginosa quorum-sensing molecule N-3-(oxododecanoyl)-L-homoserine lactone inhibits T-cell differentiation and cytokine production by a mechanism involving an early step in T-cell activation. Infect Immun 73 1648... 

---