Selective IgA deficiency

Blood donors with selective IgA deficiency have a normal gastrointestinal microflora without evidence of bacterial overgrowth [191]. In patients with complex immunodeficiency increased bacterial colonization is seen in... 

Alpha-1-Protease Inhibitor (Prolastin) [Respiratory Agent/Alpha Protease Inhibitor Replacement] Uses a,-Antit-rypsin deficiency panacinar emphysema Action Replace human aj-protease inhibitor Dose 60 mg/kg IV once/wk Caution [C, ] Contra Selective IgA deficiencies w/ known IgA antibodies Disp Inj SE Fever, dizziness, flu-like Sxs, allergic Rxns EMS Pt may have chronic lung Dz/damage, monitor resp status OD Not expected to produce life-threatening Sxs... 

Contraindications Hypersensitivity to human immunoglobulin Selective IgA deficiency ... 

Nataas OB, Nesthus I. Immune haemolytic anaemia induced by glibenclamide in selective IgA deficiency. BMJ (Clin Res Ed) 1987 295(6594) 366-7. 

Collin P, Maki M, Keyrilainen O, Hallstrom O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol 1992 27 367-371. 

Korponay-Szabo IR, Dahlbom I, Laurila K, Koskinen S, Woolley N, Partanen J, et al. Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 2003 52 1567-1571. 

Estimation of autoantibodies in CD is based mainly on detection of IgA class immunoglobulins. However, CD is associated with selective IgA deficiency [131]. About 2% of CD patients are IgA deficient in Italy [132, 133] and Ireland [134]. In cases of IgA deficiency, the corresponding IgG antibodies should be evaluated. Indirect immunofluorescent detection of IgG anti-endomysium antibodies has drawbacks due to secondary antibodies against human IgG often nonspecifically binding to connective tissue fibers [135]. However, IgG class antibodies against tTG have shown high specificity for CD in cases of IgA deficiency [136-139],... 

Several patients with selective IgA deficiency and even a panhypogammaglobulinemia during intramuscular gold treatment have been described (SEDA-14,190) (SEDA-15, 230) (SEDA-21, 237). 

Negishi M, Kobayashi K, Ide H, et al. A case report of selective IgA deficiency in rheumatoid arthritis treated with d-penicillamine. J Showa Med Assoc 1990 50 205-9. 

Cataldo F, Lio D, Marino V, Picarelli A, Venturer A, Corazza GR. IgGi antiendomysium and IgG antitissue transglutaminase antibodies in coehac patients with selective IgA deficiency. Gut 2000 47 366-9. 

Selective IgA deficiency (SIgAD) Unknown susceptibility locus termed IGAD1 in the HLA-DQ/DR region Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), coeliac disease, and many other autoimmune manifestations... 

The most common primary immunodeficiency syndromes are selective IgA deficiency (SIgAD) and common variable... 

Selective IgA deficiency (SIgAD). The most common form of primary immunodeficiency. Autoimmunity is the most prevalent manifestation of this deficiency. Individuals with SIgAD have an increased risk of developing systemic (e.g. systemic lupus... 

Hammarstrom L, Vorechovsky I, Webster D (2000) Selective IgA deficiency (SlgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol, 120(2) 225-231. 

Kralovicova J, Hammarstrom L, Plebani A, Webster ADB, Vorechovsky I (2003) Fine-scale mapping at IGAD1 and genome-wide genetic lingage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency. J Immunol, 170 2765-2775. 

Agammaglobullnaemla There is a complete absence of immunoglobulin production. Selective IgA deficiency is more common with affected children presenting with recurrent respiratory infections... 

Cowan, M., Fujiwara, P. and Ammann, A., 1980, Cellular immune defect in selective IgA deficiency using a microculture method for PHA stimulation and limiting dilution, Clin. Immunol. Immunopath., 17 595. 

Selective IgA deficiency is observed with considerable frequency (3-7 per 1,000 population). In a few patients, this may portend the development of... 

SELECTIVE IgA DEFICIENCY Inherited isolated deficiency of IgA antibodies in the serum. 

Plebani A, Ugazio AG, Monafo V. Selective IgA deficiency an update. Curr Prob Dermatol 1989 18 66-78. 

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