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Synthesis protection

Lu, A.H., Salabas, E.L. and Schuth, F. (2007) Magnetic nanoparticles synthesis, protection, functionalization, and application. Angewandte Chemie International Edition, 46 (8), 1222-1244. [Pg.80]

The fhioethyl group present in the anchor group of (40) was activated by treatment with N-iodosuccinimide (NIS) followed by displacement with a variety of alcohols (44-46). To prove the possible application of this linker in solid phase carbohydrate synthesis, protected glycosides (47) and (48) were coupled to linker (40) and released enzymatically. Flitsch et al. also described the immobilization and enzymatic cleavage on a variety of amines [41]. Nevertheless, the application of this enzyme-labile hnker group in multi-step syntheses on the solid phase and subsequent enzyme-initiated release from the polymeric support has not been described yet. [Pg.460]

The polymer-bound p-nitrobenzophenone oxime (71d) has been found to be a suitable support for stepwise peptide synthesis. Protected peptides can be assembled on 70d by coupling and deprotection steps similar to those employed in the usual Merrifield solid-phase procedures (Scheme 39). Cleavage of peptides from 71d can be accomplished with hydrazine and amino acid esters under mild conditions, which do not affect benzyl ester side-chain protecting groups. [Pg.182]

Amino Acid Protecting Groups Suitable for Solution Synthesis Protecting Groups Suitable for Solid-Phase Synthesis on HMFS Resin... [Pg.43]

Some amino acids contain functional groups that need to be masked during peptide synthesis. Protective groups suitable for the Boc strategy must be resistant towards TFA, whereas for the Fmoc strategy stability towards piperidine must be ensured. [Pg.475]

A wide range of catalysts have been reported for dehydrocoupling of OH-containing compounds with silanes. These include acids and bases and both homogeneous and heterogeneous transition-metal catalysts. Such reactions can be useful in organic synthesis (protection of OH groups), in... [Pg.389]

A second method that has been invaluable for accessing glycans is chemical synthesis (see cross references Glycan synthesis, key reaction of Glycan synthesis, key strategies for Glycan synthesis, protection and deprotection steps of and... [Pg.44]

Glycan Synthesis, Key Reactions of Glycan Synthesis, Key Strategies for Glycan Synthesis, Protection and Deprotection Steps of... [Pg.51]

Kimnra N, Nishizaki K, Orita Y, Masnda Y. 4-methyl-catechol, a potent inducer of nerve growth factor synthesis, protects spiral ganglion neurons from aminoglycoside ototoxicity—preliminary report. Acta Otolaryngol Suppl 1999 540 12-15. [Pg.132]

Severini C, Passeri PP, Ciotti M, Florenzano F, Possenti R, Zona C et al (2014) Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid- 3-induced toxicity. J Alzheimers Dis 38 281-293... [Pg.547]

A.H. Lu, E.L. Salabas, and F. Schuth Magnetic nanoparticles Synthesis, protection, functionalization, and applicatioa Angewandte Chemie-Inter-national Edition 46, 1222-1244 (2007)... [Pg.464]

Optically active 3-amino-2-hydroxycarboxylic acid derivatives are often key components of medicinally important compounds. The synthesis of isopropyl (2i ,35)-3-amino-4-cyclo-hexyl-2-hydroxybutyrate (126) (Scheme 28) takes advantage of a [2 + 2]-cycloaddition reaction of the chiral imines 123, prepared from 63, to assemble the important diastereomeric azetidinone 124 as the crucial precursor for completion of this novel synthesis. Protection of the hydroxy group of 63 as either the TBS ether 119 or the tert-buty ether 120, followed by a DIBAL reduction at —78 °C, produces smoothly one of the aldehydes 121 or 122. Condensation of these aldehydes with either di-p-anisylmethylamine or benzylamine in the presence of anhydrous magnesium sulfate affords the four possible chiral imines 123a—d (Scheme 26). [Pg.154]

Many oleane and ursane triterpenoids are reported to have interesting biological, pharmacological, and medicinal activities similar to those of retinoids and steroids. These include antiinflammatory activity, suppression of tumor promotion, suppression of immunoglobulin synthesis, protection of the liver against toxic injury, induction of collagen synthesis, and induction of differentiation in leukemia or teratocarcinoma cells [197]. [Pg.691]

Lu, A.-H., Salabas, E., Schth, F., 2007. Magnetic Nanoparticles Synthesis, Protection, Functionalization, and Application. Verlag GmbH Co. KGaA, Weinheim. [Pg.29]

An-Hui Lu, Salabas E. L., Schiith Ferdi. (2007). Magnetic Nanopartides Synthesis, Protection, Functionalization, and Apphcation, Angewandte Chemie-International, Volume 46, Issue 8, pp 1222-1244. [Pg.417]

With this chiral material (30) successfully synthesized, all the necessary stereochemical elements were now in place to enable the incorporation of the remaining stereocenters of resiniferatoxin (1) in an entirely guided manner through substrate-controlled events. Thus, proceeding forward with the execution of the synthesis, protection of the free alcohol in 30 (Scheme 8) under standard conditions provided the corresponding benzyl ether (21). [Pg.147]


See other pages where Synthesis protection is mentioned: [Pg.110]    [Pg.480]    [Pg.7]    [Pg.112]    [Pg.485]    [Pg.94]    [Pg.246]    [Pg.932]    [Pg.94]    [Pg.186]    [Pg.480]    [Pg.747]    [Pg.112]    [Pg.485]    [Pg.128]    [Pg.618]    [Pg.7]    [Pg.613]    [Pg.110]    [Pg.468]    [Pg.1403]    [Pg.120]    [Pg.173]    [Pg.280]    [Pg.2578]    [Pg.332]    [Pg.37]   
See also in sourсe #XX -- [ Pg.7 , Pg.146 ]




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Acetates, methoxyalcohol protection nucleoside synthesis

Acetates, phenoxyalcohol protection nucleoside synthesis

Amines: protection synthesis

Amino protection synthesis

Azides as Protecting Groups during Aminoglycoside Synthesis

Benzyloxycarbonyl protecting group peptide synthesis

Carbamate-protected primary amines, synthesis

Carboxyl groups, protection synthesis, from

Chemical syntheses synthesis without protections

Common Protecting Groups in Carbohydrate Synthesis

Diastereoselective synthesis, of protected vicinal amino alcohols

Enzymatic protecting group techniques organic synthesis

Merrifield solid-phase synthesis Fmoc protecting group

Multistep synthesis protecting groups

New Linkers and Protection Groups for Solid-Phase Synthesis of Oligosaccharides

Noncovalent protection, solid-phase peptide synthesis

Nucleotides: oligonucleotide syntheses protection

Oligonucleotides, solid phase synthesis protecting groups

Oligosaccharide Synthesis by Remote Activation O-Protected 3-Methoxy-2-pyridyloxy (MOP) Glycosyl Donors

Oligosaccharide Synthesis by Remote Activation O-Protected Glycosyl 2-thiopyridylcarbonate Donors

Order of Synthesis Steps to Avoid Protecting Groups

Organic synthesis functional groups protection-deprotection

Organic synthesis hydroxy groups protection

Orthogonal Protection in Library Synthesis

Orthogonal protection, solution phase synthesis

Peptide synthesis, thiol protection

Peptides protected, synthesis

Photolabile Protecting Croups in Organic Synthesis

Polymer support synthesis protecting groups

Protected vicinal amino alcohols, synthesis

Protecting Group Combinations for Solid-Phase Synthesis

Protecting Group Strategies in Carbohydrate Synthesis

Protecting Groups and Solid-Phase Synthesis

Protecting Groups for the Synthesis of Polynucleotides

Protecting Groups in Organic Synthesis

Protecting Groups in Synthesis

Protecting group free carbohydrate synthesis using

Protecting group in peptide synthesis

Protecting group nucleic acid synthesis and

Protecting group peptide synthesis and

Protecting group use in AMP synthesis

Protecting group-free flow synthesis

Protecting groups in glycopeptide synthesis

Protecting groups in oligonucleotide synthesis

Protecting groups in oligosaccharide synthesis

Protecting groups solid phase peptide synthesis

Protecting groups, deprotection solid phase peptide synthesis

Protecting groups, glycopeptide synthesis

Protecting peptide synthesis

Protecting-group-free iterative synthesis

Protecting-group-free synthesis

Protection and Deprotection Specific to Peptide Synthesis

Protective Groups in Organic Synthesis

Protective groups, hydroxamic acid synthesis

Solid phase synthesis of protected peptide fragments

Solid-phase peptide synthesis amino acid side chain protecting groups

Solid-phase peptide synthesis coupling protected amino acids

Synthesis N-protection and C-activation

Synthesis Without Protecting Croups

Synthesis continued) protected aldehyde

Synthesis enzymatic protecting group techniques

Synthesis of Cyclically Protected Side Chains

Synthesis of Protected C15- and C2o-Dialdehydes

Synthesis of protected peptide fragments

Synthesis of the Protected Dipeptide Ala-Phe-OMe

Synthesis protecting group development

Synthesis without Protections

Tert-Butoxycarbonyl, protecting group peptide synthesis

Tetrasaccharide synthesis, hydroxyl protecting groups

The Future of Chitin Synthesis Inhibitors for Crop Protection

Total synthesis protecting groups

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