Protected vicinal amino alcohols, synthesis

PROPYNYLLITHIUM LITHIUM, 1-PROPYNYL- (4529-04-8), 76, 214 Protected vicinal amino alcohols, synthesis of, 77, 78... 

DIASTEREOSELECTIVE SYNTHESIS OF PROTECTED VICINAL AMINO ALCOHOLS (S)-2-[(4S)-N-tert-BUTOXYCARBONYL-2,2-DIMETHYL-1,3-... 

Sharpless asymmetric aminohydroxylation One-pot enantioselective synthesis of protected vicinal amino alcohols from simple alkenes. 404... 

Aminohydroxylation of Alkenes. Sharpless asymmetric aminohydroxylation (AA) allows for the catalytic and enantios-elective symthesis of protected vicinal aminoalcohols in a single step. This reaction is significant as it applies to the synthesis of a wide variety of biologically active agents and natural products. For example, new monoterpene /3-amino alcohols can effectively be synthesized from (+)-2-carene, (+)-3-carene, (—)-/3-pinene, and... 

A novel approach to the synthesis of chiral vicinal amino-ketones and -alcohols depends on high enantiomeric retention in the Friedel-Crafts reaction of N-protected amino-acids (Scheme 11). ... 

Ooi T, Takeuchi M, Kato D, Uematsu Y, Tayama E, Sakai D, Maruoka K. Highly enantioselective phase-transfer-catalyzed alkylation of protected a-amino acid amides toward practical asymmetric synthesis of vicinal diamines, a-amino ketones, and a-amino alcohols. J. Am. Chem. Soc. 2005 127(14) 5073-5083. 

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