Polymer support synthesis protecting groups

Stral997 Stranix, B.R., Liu, H.Q. and Darling, G.D., Functional Polymers from (Vinyl)polystyrene. Recyclable Polymer-Supported Organosilicon Protecting Groups for Solid-Phase Synthesis, J. Org. Chem., 62 (1997) 6183-6186. 

M. J. Frechet, Tetrahedron 37, 663-683 (1981), Synthesis and Applications of Organic Polymers as Supports and Protecting Groups . 

J. M. J. Frechet, Synthesis and applications of organic polymers as supports and protecting groups. Tetrahedron 1981, 37, 663-683. 

Studies on new protecting groups were often initially conducted in solution, but in recent years, generally directed toward immediate application in polymer-support synthesis. An account of recent protecting groups is given by Sonveaux in Chapter 1 of Proto-... 

E. C. Blossey and D. C. Neckers, Eds., Solid Phase Synthesis, Halsted, New York, 1975 P. Hodge and D. C. Sherrington, Eds., Polymer-Supported Reactions in Organic Synthesis, Wiley-Interscience, New York, 1980. A comprehensive review of polymeric protective groups by J. M. J. Frechet is included in this book. 

Polymer-supported esters are widely used in solid-phase peptide synthesis, and extensive information on this specialized protection is reported annually. Some activated esters that have been used as macrolide precursors and some that have been used in peptide synthesis are also described in this chapter the many activated esters that are used in peptide synthesis are discussed elsewhere. A useful list, with references, of many protected amino acids (e.g., -NH2, COOH, and side-chain-protected compounds) has been compiled/ Some general methods for the preparation of esters are provided at the beginning of this chapter conditions that are unique to a protective group are described with that group/ Some esters that have been used as protective groups are included in Reactivity Chart 6. 

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