Orthogonal Protection in Library Synthesis

In general, an Fmoc/Boc orthogonal protecting strategy is most often used in library synthesis. Therefore, the protecting groups P and P3 in Scheme 1 are Fmoc and Boc, respectively. 

Molecular tags overcome the chemical sensitivity and orthogonal protection required by both peptide and oligonucleotide encoding. Two such methods have been developed and applied to the synthesis of both peptide and nonoligomeric libraries. One of these [34] approaches uses chemically robust haloaromatic tags which are used in a binary encoding... 

A selection of other orthogonally protected saccharide intermediates with potential for library synthesis is shown in Fig. 11 [77]. 

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