Organic synthesis functional groups protection-deprotection

Because of the nature of classical chemical reactivity, organic synthesis extensively utilizes protection-deprotection of functional groups, which increases the number of steps in synthesizing the desired target compounds (Li and Trost, 2008). Novel... 

O- and N-protection is often necessary in organic synthesis. Several recent advances in functional group protection-deprotection are particularly noteworthy. 

Electroenzymatic reactions are not only important in the development of ampero-metric biosensors. They can also be very valuable for organic synthesis. The enantio- and diasteroselectivity of the redox enzymes can be used effectively for the synthesis of enantiomerically pure compounds, as, for example, in the enantioselective reduction of prochiral carbonyl compounds, or in the enantio-selective, distereoselective, or enantiomer differentiating oxidation of chiral, achiral, or mes< -polyols. The introduction of hydroxy groups into aliphatic and aromatic compounds can be just as interesting. In addition, the regioselectivity of the oxidation of a certain hydroxy function in a polyol by an enzymatic oxidation can be extremely valuable, thus avoiding a sometimes complicated protection-deprotection strategy. 

The protection of certain functional groups and the deprotection of the protected derivatives constitute important processes in the synthetic organic chemistry of polyfunctional molecules, including the total synthesis of natural products. Following are examples demonstrating some important improvements to the conventional methods for defense group deprotections. 

Chapter 1 is devoted to exploring strategies involved in organic synthesis. It seeks to explain concepts like retrosynthetic analysis, atom economy, umpolung approach, click chemistry and asymmetric synthesis. On the basis of interesting and relevant examples, protection and deprotection of different functional groups are explained and the most probable mechanism is also mentioned for important reactions. 

Molecular iodine An efficient reagent for numerous organic strategies (synthesis of various heterocychc compounds, iodination, protection— deprotection of functional groups etc.) 12COC1485. 

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