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Alkylation synthesis

Williamson ether synthesis Alkyl halides react with sodium or potassium alkoxides or phenox-ides to give ethers. [Pg.426]

Wuftz synthesis Alkyl halides react with sodium in dry ethereal solution to give hydrocarbons. If equimolecular amounts of two different halides are used, then a mixture of three hydrocarbons of the types R — R, R — R and R —R, where R and R represent the original radicals, will be formed. The yields are often poor owing to subsidiary reactions taking place. [Pg.427]

Section 21 7 The malonic ester synthesis is related to the acetoacetic ester synthesis Alkyl halides (RX) are converted to carboxylic acids of the type RCH2COOH by reaction with the enolate ion derived from diethyl mal onate followed by saponification and decarboxylation... [Pg.907]

A method that achieves the same end result as that desired by alkylation of ammonia but which avoids the formation of secondary and tertiary amines as byproducts is the Gabriel synthesis Alkyl halides are converted to primary alkylamines without contam mation by secondary or tertiary amines The key reagent is the potassium salt of phthal imide prepared by the reaction... [Pg.929]

Among compounds other than simple alkyl halides a halo ketones and a halo esters have been employed as substrates m the Gabriel synthesis Alkyl p toluenesul fonate esters have also been used Because phthalimide can undergo only a single alkyl ation the formation of secondary and tertiary amines does not occur and the Gabriel synthesis is a valuable procedure for the laboratory preparation of primary amines... [Pg.930]

Induction of Asymmetry by Amino Acids. No fewer than sis types of reactions can be carried out with yields of 75—100% usiag amino acid catalysts, ie, catalytic hydrogenation, iatramolecular aldol cyclizations, cyanhydrin synthesis, alkylation of carbonyl compounds, hydrosdylation, and epoxidations (91). [Pg.282]

Sandmeyer s synthesis of aromatic nitriles is far more elegant than the removal of water from the ammonium salts of carboxylic acids, which latter reaction is also applicable to benzene derivatives. In particular, the former synthesis permits of the preparation of carboxylic acids via the nitriles, and so provides a complete substitute for Kolbe s synthesis (alkyl halide and potassium cyanide), which is inapplicable to aromatic compounds. The simplest example is the conversion of aniline into benzoic add. The converse transformation is Hofmann s degradation (benzamide aniline, see p. 152). [Pg.293]

Uses Intermediate for production of tetraethyl lead and ethyl cellulose topical anesthetic organic synthesis alkylating agent refrigeration analytical reagent solvent for phosphorus, sulfur, fats, oils, resins, and waxes insecticides. [Pg.289]

Sodium toluene dispersion of, 55, 65 Sodium p-toluenesulfinate, 57, 103 Spiro[4 n] alkenones, 58, 62 Spiro[cyclopentane-l,l -indene] 55, 94 Squalene, 56, 116 Squalene, 2,3-epoxy, 56, 116 Stannic chloride, 56, 97 Steroids synthesis, 58, 85 E Stilbene, 55, 115,58, 73 z-Stilbene, 58, 133 Styrene, 56, 35,58, 43 Styrene glycol, 55, 116 Styrene glycol dimesylate, 55, 116 Succinic acid, 58, 85 Succinic anhydride, 58, 85 Sucunimide, 56, 50, 58, 126 Succimmide, Vbromo, 55, 28, 56, 49 SULFIDE CONTRACTION, 55, 127 Sulfide, dimethyl-, 56, 37 SULFIDE SYNTHESIS, 58, 143,58, 138 SULFIDE SYNTHESIS ALKYL ARYL SULFIDES, 58, 143 SULFIDE SYNTHFSIS DIALKYL SULFIDES, 58, 143 SULFIDE SYNTHESIS UNSYMMETRI-CAL DIALKYL DISULFIDES, 58, 147 SULFONYL CYANIDES, 57, 88 Sulfur tetrafluoride, 57, 51... [Pg.192]

Ester-substituted ketone enolates are stabilized, and these enolates can be alkylated (ace-toacetic ester synthesis). Alkylation is, however, also possible for enolates that are not stabilized. In the case of the stabilized enolates, the alkylated ketones are formed in two or three steps, while the nonstabilized enolates afford the alkylated ketones in one step. However, the preparation of nonstabilized ketone enolates requires more aggressive reagents than the ones employed in the acetoacetic ester synthesis. [Pg.546]

The trans allylic alcohol needed to make this compound was made using one of the methods we introduced in Chapter 3i reduction of an alkynyl alcohol with LiAlEL]. Here is the full synthesis alkylation of an ester enolate with prenyl bromide gives a new ester, which itself is turned into an alkylating agent by reduction and tosylation. The alkyne is introduced as its lithium derivative with the alcohol protected as a THP acetal. Hydrolysis of the acetal with aqueous acid gives the hydroxy-alkyne needed for reduction to the E double bond, which is then epoxidized. [Pg.883]

To obtain oiehns in the pure state, intended for other uses than alkylation (oxo synthesis, alkyl sulfates), ffiey can be separated by selective and leversiUe adsorption on sc ds. UOP employs a tedinique designated Olex , whidi is similar in principle to that of its Molex and Parex processes. [Pg.188]

A number of partial syntheses which have been mentioned earlier in this chapter e.g. rosenonolactone), may be considered as formally total by virtue of the previous synthesis of an intermediate. The compound (124) features as an intermediate in diterpene total synthesis. Alkylation with methyl iodide gave a mixture of C-13 epimeric aldehydes which were converted " into pimara-8(14),15-dien-19-oic acid and its C-13 epimer the former occurs in Aralia cordata. [Pg.152]

Alkyl Ureas.—By substituting alkyl amines for ammonia in the reaction for the synthesis of urea from carbonyl chloride, or by using alkyl derivatives of ammonium cyanate (cyanic acid salts of alkyl amines), in the Wohler synthesis, alkyl ureas may be obtained. They are of different t es as illustrated by the following formulas showing their relationship to urea. [Pg.436]

Stork enamine synthesis Alkylation of enamines with alkyl halides to afford a-alkylated aldehydes or ketones. 444... [Pg.510]

Williamson ether synthesis Alkylation of alkali alkoxides with primary or secondary alkyl halides to form ethers. 484... [Pg.510]

Triethylamine was used by a Ciba-Basel group in different ways in two successive steps of a steroid total synthesis. Alkylation of the 1,3-diketone (2) with the halide (1) was accomplished by reaction in t-butanol under catalysis by triethylamine. Intramolecular aldolization of (3) with elimination of water to close ring C required... [Pg.1334]

Use Organic synthesis (alkylating agent), solvent, anthelmintic. [Pg.197]


See other pages where Alkylation synthesis is mentioned: [Pg.130]    [Pg.315]    [Pg.315]    [Pg.150]    [Pg.201]    [Pg.130]    [Pg.735]    [Pg.182]    [Pg.1094]    [Pg.173]    [Pg.130]    [Pg.34]    [Pg.182]    [Pg.404]    [Pg.197]   
See also in sourсe #XX -- [ Pg.3 , Pg.50 ]




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1,4-Benzoquinone, 2-alkyl-3- synthesis

2- Alkyl thiazoles, nitration synthesis

2- Alkyl-4-thiazolecarboxylic acid, synthesis

2- Alkyl-6-methyl pyridine synthesis

2-Alkyl-27/-isoindoles, synthesis

4-Alkyl-7-lactones, synthesis

5-Alkylation thioacetates, synthesis

A Synthesis of 3-Alkyl-l-Naphthols

A-alkylated enantioselective synthesis

A-alkylated synthesis

Aldehydes, aromatic, synthesis from alkyl halides

Alkene Synthesis by Elimination of Alkyl Halides

Alkyl aryl ketones, synthesis

Alkyl aryl sulphoxides synthesis

Alkyl asymmetric synthesis

Alkyl benzenes synthesis

Alkyl biphenyl carboxylates, synthesis

Alkyl bromides synthesis from alcohols

Alkyl bromides synthesis, silver® oxide

Alkyl chlorides synthesis from alcohols

Alkyl cobalamins synthesis

Alkyl complexes synthesis

Alkyl compounds synthesis

Alkyl compounds, conjugate synthesis

Alkyl cyanides, synthesis

Alkyl derivatives heterocyclic synthesis, intramolecular

Alkyl derivatives natural product synthesis applications

Alkyl derivatives natural products synthesis

Alkyl derivatives organic synthesis

Alkyl enzymatic synthesis

Alkyl fluorides synthesis

Alkyl fluorides synthesis carboxylic acids

Alkyl fluorides synthesis fluorination

Alkyl fluorides synthesis nucleophilic substitution

Alkyl formates, synthesis

Alkyl formates, synthesis from

Alkyl glycosides, synthesis

Alkyl glycosides, synthesis preparative usefulness

Alkyl hahde synthesis

Alkyl halide malonic ester synthesis with

Alkyl halides alcohol synthesis

Alkyl halides asymmetric syntheses

Alkyl halides enantioselective synthesis

Alkyl halides in Gabriel synthesis of amines

Alkyl halides in Williamson ether synthesis

Alkyl halides in synthesis

Alkyl halides nitrile synthesis

Alkyl halides synthesis

Alkyl halides, hydroperoxide synthesis

Alkyl halides. Gabriel synthesis

Alkyl halides—continued synthesis

Alkyl hydroperoxides synthesis

Alkyl indole-2-carboxylates, synthesis

Alkyl iodides, synthesis

Alkyl isothiocyanates, synthesis from

Alkyl metals, a-selenocarbonyl compound homologation synthesis

Alkyl polyglycosides synthesis

Alkyl polymer synthesis

Alkyl pyrophosphates, synthesis

Alkyl quinolizines, synthesis

Alkyl sulfonates synthesis

Alkyl sulfoximines synthesis

Alkyl synthesis

Alkyl synthesis

Alkyl zinc complexes, synthesis

Alkyl, amines Synthesis

Alkyl-sulfoxides synthesis

Alkylated pseudoephedrine amides synthesis

Alkylation amine synthesis

Alkylation carboxylic acid synthesis

Alkylation cumene synthesis

Alkylation diastereoselective synthesis

Alkylation glycoside synthesis

Alkylation natural product synthesis

Alkylation reactions acid synthesis

Alkylation, enolate ions synthesis

Alkylations substituted alkene synthesis

Allylic alkylation synthesis

Aluminum alkyls direct synthesis

Amine Synthesis by A-Alkylation

Amino acids simple alkylation synthesis

Aryl alkyl ethers Williamson synthesis

Aryl alkyl thioethers, synthesis

Asymmetric synthesis alkylation

Asymmetric synthesis allylic alkylation

Azides, alkyl synthesis

Benzo furans, alkyl synthesis

Bicyclo alkyl synthesis

Bromides alkyl, synthesis

C-Alkylation in the Schollkopf Synthesis

Carbothioates, P-oxoO-alkyl esters synthesis

Carbothioates, p-hydrazonoO-alkyl esters synthesis

Carboxylic acids synthesis from alkyl halides

Chiral alkyl halides synthesis

Chlorides, alkyl, synthesis

Crown ethers, higher alkyl, synthesis

Cyclopentenone, 3-alkyl-4- synthesis

Cyclopentenones, 3-alkyl-4- synthesis

Drag synthesis alkylation

Enantioselective synthesis alkylation

Enhancer alkyl benzene synthesis

Enzymatic Synthesis of Alkyl Glycosides with Ionic Liquid as a Modulator

Ethers, alkyl methyl synthesis

Ethers, aryl alkyl synthesis

Ethyl methyl ether, synthesis from alkyl

Exhaustive alkylation synthesis

Formates, alkyl chloroanhydride synthesis

Formates, alkyl chloroanhydride synthesis dimethylformamide adducts

Formates, alkyl chloroanhydride synthesis reactions with amides

Friedel-Crafts Alkylation of Arenes in Total Synthesis

Friedel-Crafts, alkylation ketone synthesis

Furan, tetrahydroarene alkylation synthesis

Grignard reagents synthesis from alkyl halides

Guanidines, alkyl synthesis

Heterocycle library synthesis alkylation

Hydroxamates, O-acyl selenodecomposition synthesis of alkyl 2-pyridyl selenides

Indoles, 2-alkyl-, synthesis

Internal alkylation synthesis

Ketones a-alkylated, synthesis

O-Alkylation glycoside synthesis

O-alkylation synthesis

Olefin alkylation, synthesis

Organolithium reagents synthesis from alkyl halides

Other Alkylations for a-Amino Acid Synthesis

Phenyl vinyl sulfones alkylation synthesis

Phosphorane, dibromotriphenylacid halide synthesis alkyl alcohols

Phosphorane, iminovinylidenetriphenylphosphonium ylide synthesis reactions with alkyl halides

Phosphorane, oxovinylidenetriphenylreactions with alkyl halides synthesis

Primary alkyl alcohol synthesis

Primary alkyl halides synthesis

Primary alkyl halides synthesis from acid chlorides

Pyridines, 2-alkyl catalytic synthesis

SULFIDE SYNTHESIS ALKYL ARYL SULFIDES

SYNTHESIS OF ALCOHOLS FROM ALKYL HALIDES

SYNTHESIS OF ALKYL HALIDES

Secondary alkyl halides synthesis

Selenides, alkyl 2-pyridyl synthesis

Selenides, aryl alkyl synthesis

Selenides, nor-alkyl-2-pyridyl synthesis

Silane, a-phenylthiomethyltrimethylreaction with alkyl halides synthesis of aldehydes

Silver cyanide, reaction with alkyl halides in synthesis of isocyanides

Sulfides, alkyl 2-pyridyl synthesis

Sulfides, alkyl aryl synthesis

Sulfides, alkyl synthesis

Syntheses involving alkylation of organoboranes

Syntheses of Alkylidene cyclobutanes from 1-Alkyl-l-selenocyclobutanes

Syntheses using aluminum alkyls

Synthesis alkyl-thiol-capped

Synthesis and Reactions of Functionalized Alkyl Boron Derivates

Synthesis from metal alkyls/hydrides

Synthesis of Alkyl Chlorides

Synthesis of Alkyl Complexes by Other Methods

Synthesis of Alkyl Complexes by Transmetallation

Synthesis of Alkyl Fluorides

Synthesis of Alkyl-ACP

Synthesis of Amines by Alkylation

Synthesis of Metal-Alkyl Complexes

Synthesis of Precision Alkyl-Branched Polyolefins

Synthesis of alkyl-D-fructosides

Synthesis routes deprotection/alkylation

Tertiary alkyl halides synthesis

Thioketones, 4-alkyl synthesis

Total Synthesis Involving Intramolecular FC Alkylations

Transition metal alkyl compounds synthesis

Williamson ether synthesis, phenyl alkyl ethers

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