Total Synthesis Involving Intramolecular FC Alkylations

Intramolecular FC alkylation is a powerful tool for the construction of cyclic structures. Depending on the length and composition of the linker between the arene and the electrophilic group and the reaction conditions, a large variety of saturated or unsaturated homocyclic or heterocyclic compounds can be obtained. 

FRIEDEL-CRAFTS ALKYLATION OF ARENES IN TOTAL SYNTHESIS 

SCHEME 2.7 Synthesis of dihydrexidine hydrochloride via an FC reaction of aminoalcohol 49. 

SCHEME 2.8 Formal synthesis of dihydrexidine via an aziridination-FC pathway. 

3 Synthesis of (-)-8-Demethoxyrunanine and (-)-Cepharatine D An intramolecular FC reaction on dihydroindolone 73 is the key step in the enantioselective syntheses of the hasubanan 

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