Alkyl cobalamins synthesis

In biochemistry, metal hydrides such as NaBH4 have been widely used in synthesis. For example, NaBH4 has been used in the preparation of alkyl cobalamins from cyanocobalamin , and in the synthesis of the chiral [/3,y- 0 7 0, 0]ATPyS from the 5 -aldehyde of adenosine . Lithium triethylborohydride (also known as Su-... 

Cobalamin catalysed reduction of alkyl halides has found use in organic synthesis because, like square planar Ni(o), it allows formation of alkyl radicals in the bulk of the solution away from the electi ode surface. Alkyl radical addition to activated alkenes is achieved in high yields. In the cases of primary alkyl halides,... 

The clarification of the structure of coenzyme B g stimulated attempts to synthesize the compound from vitamin B g and an activated adenosine derivative. Smith et described a chemical synthesis of the coentyme from fully reduced vitamin Big (Bi and the 5 -tosyl-2, 3 -isopropylidene derivative of adenosine. At the same time they reported the synthesis of Co-methyl-cobalamin from Bigg and methyl iodide. Soon thereafter a biological function of methylcobalamin in the methylation of homo steine was demonstrated by Guest et Only one other Co-alkyl-corrinoid compound has so far been... 

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