Ester, synthesis

By the malonic ester synthesis (compare Section 111,165), for example ... [Pg.753]

The thermal decarboxylation of malonic acid derivatives is the last step m a multistep synthesis of carboxylic acids known as the malonic ester synthesis This synthetic method will be described m Section 21 7... [Pg.818]

The thermal decarboxylation of p keto acids is the last step in a ketone synthesis known as the acetoacetic ester synthesis The acetoacetic ester synthesis is discussed in Section 21 6... [Pg.819]

This reaction sequence is called the acetoacetic ester synthesis It IS a standard... [Pg.895]

The acetoacetic ester synthesis brings about the overall transformation of an alkyl halide to an alkyl derivative of acetone... [Pg.895]

The malonic ester synthesis is a method for the preparation of carboxylic acids and is represented by the general equation... [Pg.897]

The malonic ester synthesis is conceptually analogous to the acetoacetic ester synthesis The overall transformation is... [Pg.897]

The properties of diethyl malonate that make the malonic ester synthesis a useful procedure are the same as those responsible for the synthetic value of ethyl acetoacetate The hydrogens at C 2 of diethyl malonate are relatively acidic and one is readily removed on treatment with sodium ethoxide... [Pg.897]

Among the methods for preparing carboxylic acids carboxylation of a Grignard reagent and preparation and hydrolysis of a nitrile convert RBr to RCO2H The malonic ester synthesis converts RBr to RCH2CO2H... [Pg.897]

In a typical example of the malonic ester synthesis 6 heptenoic acid has been pre pared from 5 bromo 1 pentene... [Pg.898]

By performing two successive alkylation steps the malonic ester synthesis can be applied to the synthesis of a a disubstituted derivatives of acetic acid... [Pg.899]

The malonic ester synthesis has been adapted to the preparation of cyclo alkanecarboxyhc acids from dihaloalkanes... [Pg.899]

Section 21 6 The acetoacetic ester synthesis is a procedure in which ethyl acetoac etate is alkylated with an alkyl halide as the first step in the preparation... [Pg.907]

Section 21 7 The malonic ester synthesis is related to the acetoacetic ester synthesis Alkyl halides (RX) are converted to carboxylic acids of the type RCH2COOH by reaction with the enolate ion derived from diethyl mal onate followed by saponification and decarboxylation... [Pg.907]

The most widely used method for the laboratory synthesis of a ammo acids is a modification of the malonic ester synthesis (Section 21 7) The key reagent is diethyl acetamidomalonate a derivative of malonic ester that already has the critical nitrogen substituent m place at the a carbon atom The side chain is introduced by alkylating diethyl acetamidomalonate m the same way as diethyl malonate itself is alkylated... [Pg.1122]

Acetoacetic ester synthesis (Section 21 6) A synthetic method for the preparation of ketones in which alkylation of the enolate of ethyl acetoacetate... [Pg.1274]

Another ester synthesis employs the reaction of a long-chain ketone and pentaerythritol in xylene or chlorobenzene (14). Mixed esters have been produced using mixed isostearic and cyclohexane carboxyUc acids in trihromophosphoric acid, followed by reaction with lauric acid (15). [Pg.464]

A number of specific Upases are used for ester synthesis (eq. 4) transesterification, eg, acidolysis with 1,3 specific Hpase (eq. 5) and hydrolysis reactions, eg, with nonspecific Hpase (eq. 6). [Pg.300]

Azabicyclo[4.2.l]nona-2,4-diene-9-carboxylic acid, 7-0X0-ethyl ester synthesis, 7, 524 Azabi cyclononadienones synthesis, 7, 524 1 -Azabi cyclo[5.2.0]nonane nomenclature, 7, 342... [Pg.519]

H-Azepine, 2,6,7-tri(methoxycarbonyl)-ring inversion, 7, 499 Azepine-1-carboxylic acid tricarbonylruthenium complexes, 7, 523 1 H-Azepine-2,3-dicarboxylic acid, 4,7-dihydro-6-phenyl-diethyl ester synthesis, 7, 539-540 1 H-Azepine-3,6-dicarboxylic acid... [Pg.523]

Benzimidazole-2-carboxylic acid decarboxylation, 5, 435 Benzimidazole-3-carboxylic acid, 1-hydroxy-ethyl ester synthesis, 6, 407 Benzimidazoles acidity, 5, 50, 385, 386 acylation, 5, 71, 391, 402, 417 2V-alkyl-... [Pg.538]

Benzo[h]selenophene-2-carboxylic acids ethyl ester synthesis, 4, 959 reactions, 4, 952 synthesis, 4, 95... [Pg.554]

Benzo[b]thiophene-2-carboxylic acid, 3-acetamino-ethyl ester synthesis, 4, 875... [Pg.561]

Benzo[c]thiophene-l,3-dicarboxylic acid dimethyl ester synthesis, 4, 903... [Pg.561]

Chroman-2-carboxylic acid, 2-hydroxy-4-oxo-ethyl ester synthesis, 3, 852... [Pg.578]

Coumarin brightening agents, 1, 339-340 Coumarin-4-carboxylic acid methyl ester synthesis, 3, 806 synthesis, 3, 809... [Pg.587]

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