Surface enhanced Raman spectroscopy detection

Nirode, W. R, Devault, G L., Sepaniak, M. J., and Cole, R. O., On-column surface-enhanced Raman spectroscopy detection in capillary electrophoresis using running buffers containing silver colloidal solutions. Ana/. Chem., 72,1866, 2000. 

Surface-Enhanced Raman Spectroscopy Detection of Hyaluronic Acid A Potential Biomarker for Osteoarthritis... 

Carrabba M.M., Edmonds R.B., Rauh, R.D., Feasibility studies for the detection of organic-surface and subsurface water contaminants by surface-enhanced Raman-spectroscopy on silver electrodes, Anal. Chem. 1987 59 2559-2563. 

Ni F., Sheng R.S., Cotton T.M., Flow-injection analysis and real-time detection of RNA bases by surface-enhanced Raman-spectroscopy, Anal. Chem. 1990 62 1958-1963. 

Roth, E. Kiefer, W., Surface enhanced Raman spectroscopy as a detection method in gas chromatography, Appl. Spectrosc. 1994,48, 1193 1195... 

The goal of this chapter will be to provide an overview of the use of planar, optically resonant nanophotonic devices for biomolecular detection. Nanophotonics23 24 represents the fusion of nanotechnology with optics and thus it is proposed that sensors based on this technology can combine the advantages of each as discussed above. Although many of the issues are the same, we focus here on optical resonance rather than plasmonic resonance (such as is used in emerging local SPR and surface-enhanced Raman spectroscopy-based biosensors). 

I.H. Chou, M. Benford, H.T. Beier, et al. Nanofluidic biosensing for )3-amyloid detection using surface enhanced Raman spectroscopy. Nano Lett., 8, 1729-1735 (2008). 

Hayazawa, N., Motohashi, M., Saito, Y, and Kawata, S. 2005. Highly sensitive strain detection in strained silicon by surface enhanced Raman spectroscopy. Appl. Phys. Lett. 86 263114. 

Bompart et al. [125] reported the synthesis of composite nanoparticles of approximately 500 nm diameter consisting of a polymer core, a layer of gold nanoparticles attached to the core, and a few nanometers thick MIP outer layer (Fig. 13). These particles were used as individually addressable nanosensors, where surface-enhanced Raman spectroscopy was used to detect the binding of the target analyte, the beta-antagonist propranolol. A l,000x improved detection limit was... 

Since most biomolecules normally exhibit medium or low Raman cross sections, an enhancement of the signal intensity for the ability to characterize even low concentrations would be preferable. Besides the application of resonance Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS) is a promising alternative. In doing so the vicinity of molecules to rough noble metal surfaces leads to Raman enhancement factors of 106-108 and even up to 1014 leading to a single molecule detection limit [9]. 

The application of surface-enhanced Raman spectroscopy (SERS) for monitoring redox and other processes at metal-solution interfaces is illustrated by means of some recent results obtained in our laboratory. The detection of adsorbed species present at outer- as well as inner-sphere reaction sites is noted. The influence of surface interaction effects on the SER spectra of adsorbed redox couples is discussed with a view towards utilizing the frequency-potential dependence of oxidation-state sensitive vibrational modes as a criterion of reactant-surface electronic coupling effects. Illustrative data are presented for Ru(NH3)63+/2+ adsorbed electrostatically to chloride-coated silver, and Fe(CN)63 /" bound to gold electrodes the latter couple appears to be valence delocalized under some conditions. The use of coupled SERS-rotating disk voltammetry measurements to examine the kinetics and mechanisms of irreversible and multistep electrochemical reactions is also discussed. Examples given are the outer- and inner-sphere one-electron reductions of Co(III) and Cr(III) complexes at silver, and the oxidation of carbon monoxide and iodide at gold electrodes. 

Zhang X, Young MA, Lyandres O, Van Duyne RP. Rapid detection of an anthrax biomarker by surface-enhanced Raman spectroscopy. Journal of the American Chemical Society 2005, 127, 4484-4489. 

The extremely small cross sections for conventional Raman scattering, typically 10 111 to 10-25 cm2/molecule has in the past precluded the use of this technique for single-molecule detection and identification. Until recently, optical trace detection with single molecule sensitivity has been achieved mainly using laser-induced fluorescence [14], The fluorescence method provides ultrahigh sensitivity, but the amount of molecular information, particularly at room temperature, is very limited. Therefore, about 50 years after the discovery of the Raman effect, the novel phenomenon of dramatic Raman signal enhancement from molecules assembled on metallic nanostructures, known as surface-enhanced Raman spectroscopy or SERS, has led to ultrasensitive single-molecule detection. 

Chemiluminescence is a very sensitive and selective technique. Reagent types, analytes, and detection limits have been summarized in a review by Imai.56 Chemiluminescence has been applied to the analysis of compounds that exhibit low UV absorbance, including metal ions, amino acids, fatty acids, and bile acids. Other detectors include detectors for radioactivity, nuclear magnetic resonance (NMR), and surface-enhanced Raman spectroscopy. Radioactivity detection is one of the most selective detectors, as only components that have been radiolabeled will be detected. The interface of NMR with HPLC and has been discussed in detail by Grenier-Loustalot et al.57 Surface-enhanced Raman spectroscopy is another technique that... 

Analyzes of the calculated IR and Raman spectra point out to the enhancement of the P=0 stretching mode with respect to the isolated DFP, and this property could be used to detect nerve-agents using surface-enhanced Raman spectroscopy. 

Surface-Enhanced Raman Spectroscopy (SERS) SERS is a technique for increasing the sensitivity of a Raman instrument. This module explores its application to the detection of chemicals indicative of brain injury. 

The use of surface-enhanced Raman spectroscopy (SERS) for trace explosive detection was first investigated during the late 1990s [48], Thereafter [49], SERS detection of 2,4-DNT vapor to 1 ppb was demonstrated. Within a year [50], a field-portable unit had demonstrated a limit of detection (LOD) of 5 ppb vapor DNT and the ability to locate buried land mines. More recently [51], nano-engineered SERS substrates have been employed, and ppb sensitivity for some nerve agent and explosive simulants has been demonstrated. Baker et al. [52] have published a review of the literature in 2005, focusing on SERS techniques and substrate development, for explosives detection. 

Hu J, Zheng P-Ch, Jiang J-H, Shen G-L, Yu R-Q, Liu G-K (2008) Electrostatic interaction based approach to thrombin detection by surface-enhanced Raman spectroscopy. Anal Chem 81 87-93... 

Ochsenkuehn MA, Campbell CJ (2010) Probing biomolecular interactions using surface enhanced raman spectroscopy label-free protein detection using a g-quadmplex dna aptamer. Chem Comm 16 2799-2801... 

Moger J, Gribbon AP, Sewing A, Winlove MG (2007) Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation. Biochim Biophys Acta 1770(6) 912-918... 

Chu H, Wang J, Ding L, Yuan D, Zhang Y, Liu J, Li Y (2009) Decoration of gold nanoparticles on surface-grown single-walled carbon nanotubes for detection of every nanotube by surface-enhanced Raman spectroscopy. J Am Chem Soc 131 14310-14316... 

Zhang ZL, Yin YF, Jiang JW, Mo YJ (2009) Single molecule detection of 4-dimethylaminoazobenzene by surface-enhanced Raman spectroscopy. J Mol Struct... 

Bell SEJ, Sirimuthu NMS (2006) Surface-enhanced Raman spectroscopy (SERS) for sub-micromolar detection of DNA/RNA mononucleotides. J Am Chem Soc 128 15580-15581... 

Lowe AJ, Huh YS, Strckland AD, Erickson D, Ban CA (2010) Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy. Anal Chem 82(13) 5810-5814... 

Zhang XY, Zhao J, Whitney AV, Elam JW, Van Duyne RP (2006) Ultrastable substrates for surface-enhanced Raman spectroscopy AI2O3 overlayers fabricated by atomic layer deposition yield improved anthrax biomarker detection. J Am Chem Soc 128 10304—10309... 

Ruan C, Wang W, Gu B (2006) Rapid and ultra-sensitive detection of alkaline phosphatase using surface enhanced Raman spectroscopy. Anal Chem 78 3379-3384... 

El Amri C, Baron M-H, Maurel M-C (2003) Adenine and RNA in mineral samples surface-enhanced Raman spectroscopy (SERS) for picomole detections. Spectrochim Acta A 59 2645-2654... 

Near-infrared surface-enhanced Raman spectroscopy Some of the major irritants in Raman measurements are sample fluorescence and photochemistry. However, with the help of Fourier transform (FT) Raman instruments, near-infrared (near-IR) Raman spectroscopy has become an excellent technique for eliminating sample fluorescence and photochemistry in Raman measurements. As demonstrated recently, the range of near-IR Raman techniques can be extended to include near-IR SERS. Near-IR SERS reduces the magnitude of the fluorescence problem because near-IR excitation eliminates most sources of luminescence. Potential applications of near-IR SERS are in environmental monitoring and ultrasensitive detection of highly luminescent molecules [11]. 

We report on application of Ag nanoparticles in high sensitive surface-enhanced Raman spectroscopy to detect low quantity of art pigments. 

SURFACE-ENHANCED RAMAN SPECTROSCOPY OF SPIRO COMPOUNDS A ROUTE FOR DIRECT DETECTION AND IDENTIFICATION OF THEIR PHOTODEGRADATION PRODUCTS... 

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