Sulpiride effects

Administration of sulpiride or SCH 23390 alone did not alter the striatal or nigral content of Dyn. Blockade of Dj receptors substantially interfered with the METH-induced changes in both striatal and nigral Dyn levels. Blockade of D2 receptors by sulpiride appeared to attenuate the METH-related changes in the Dyn levels, especially in the substantia nigra, but its interference with the METH effects was less than that of the SCH 23390 compound. 

Antidepressant effects Hypericum has been shown to have antidepressant effects in several animal models. An extract fraction high in naphthodianthrones showed antidepressant effects in the forced-swim test, and was attenuated by a dopamine antagonist (sulpiride) (Butterweck et... 

Frantz KJ, Van Hartesveldt C. 1995. Sulpiride antagonizes the biphasic locomotor effects of quinpirole in weanling rats. Psychopharmacology (Berl) 119(3) 299-304. 

The conventional antipsychotics have little effect on the negative psychotic symptoms such as autism, stupor and emotional withdrawal. The so-called atypical antipsychotics, or second-generation antipsychotics, like the heterocyclic compound risperidone, the benzamide sulpiride and several diben-zepines of which clozapine is the best known, have a broader spectrum which means that they also have an effect on the negative psychotic symptoms. Most share a common attribute of working on serotonin receptors as well as dopamine receptors. They have a low risk of extrapyramidal side effects. 

In an uncontrolled retrospective study of 63 patients with TS, ages 10-68 years, many of whom were on other medications, sulpiride produced a positive response in 60% of subjects (Robertson et ah, 1990). The modal daily dose of responders was 400 mg (dose range 200-1000 mg/day). Drowsiness, depression, ak-athisia, and weight gain were common side effects. 

Kahn NH, Shelton SJ Defensive behaviors in infant rhesus monkeys environmental cues and neurochemical regulation. Science 243 1718-1721, 1989 Kahnowsky LB, Kennedy F Observations in electric shock therapy apphed to problems of epilepsy. J Nerv Ment Dis 98 56-67, 1943 Kampen D, Sherwin B Estrogen use and verbal memory in healthy postmenopausal women. Obstet Gynecol 83 979-983, 1994 Kane JM, Quitkin FM, Rifkin A, et al Lithium carbonate and imipramine in the prophylaxis of unipolar and bipolar 11 illness a prospective placebo-controlled comparison. Arch Gen Psychiatry 39 1065-1069, 1982 Kaneno S, Komatsu H, Fukamauchi F, et al Biochemical basis of antidepressant-effect of low dose of sulpiride. Japanese Journal of Psychiatry and Neurology 45 131-132, 1991... 

Serra G, Forgioni A, D Aquila PS, et al Possible mechanism of antidepressant effect of L-sulpiride. Chn Neuropharmacol 13 (suppl l 576-583, 1990a Serra G, CoUn M, D Aquila PS, et al Possible role of dopamine D1 receptor in the behavioral supersensitivity to dopamine agonists induced by chronic treatment with antidepressants. Brain Res 527 234-243, 1990b Sershen H, Hashim, A, Lajtha A Behavioral and biochemical effects of nicotine in an MPTP-induced mouse model of Parkinson s disease. Pharmacol Biochem Behav 28 299-303, 1987... 

Antipsychotic drugs with strong sedative clinical effects (e.g. chlorpromazine. clozapine, olanzapine) produce subjective and objective sedation and impair most areas of performance in healthy volunteers, usually at doses far below those typically used in patients. Antipsychotic drugs with little sedative clinical action (e.g. pimozide, sulpiride, amisulpride) produce few subjective and objective effects in healthy... 

Meyer-Lindenberg, A., Rammsayer, T., Ulferts, J., Gallhofer, B. The effects of sulpiride on psychomotor performance and subjective tolerance. Eur. Neuropsychopharmacol. 7, 219-223, 1997. 

When selenium is heated with a metallic oxide or carbonate, a mixture of selenide and selenite is commonly obtained. At high temperatures selenium is able to displace sulphur partially from sulphides such as copper sulphide and silver sulpiride, the effect probably being due to selenium being less volatile than sulphur.10 At ordinary temperatures... 

Loftier et al. 2006). Coadministration of sulpiride and fluvoxamine, a serotonin reuptake inhibitor, increased in vivo dopamine release in the prefrontal cortex of rats (Ago et al. 2005a). The increase probably is the neurochemical counterpart of the antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice, as measured in the tail suspension test (Ago et al. 2005b). A recent clinical trial showed superior antidepressant efficacy of the combination of sulpiride plus the serotonin reuptake inhibitor paroxetine compared with paroxetine alone and, importantly enough, an accelerated antidepressant response of the combination (Uchida et al. 2005). 

Ago Y, Harasawa T, Itoh S, Nakamura S, Baba A, Matsuda T (2005b) Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice. Eur J Pharmacol 520 86-90 Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, Greengard P, Aperia A (2000) Anatomical and physiological evidence for Di and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci 3 226-30... 

Engleman EA, McBride WJ, Li TK, Lumeng L, Murphy JM (2003) Ethanol drinking experience attenuates (—)sulpiride-induced increases in extracellular dopamine levels in the nucleus ac-cumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res 27 424-31 Ennis C, Kemp JD, Cox B (1981) Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem 36 1515-20 Ensinger H, Majewski H, Hedler L, Starke K (1985) Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits. J Pharmacol Exp Ther 234 681-90... 

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