Strychnos vomica

Sixteen alkaloids have been isolated from the seeds of Strychnos vomica L [82]. This journal (Acta Pharmaceutica Sinica) being difficult to access, we report in Table 4 the 13C NMR chemical shifts for 2-hydroxy-3-methoxystrychnine (12), isostrychnine (13), isobrucine (14), isostrychnine-Af-oxide (15) and isobrucine-Af-oxide (16) which are new compounds. 

Brucine, C2aH2e04N2. Brucine was first obtained in 1819 by Pelletier and Caventou from Strychnos Nux-vomica bark, then supposed to be derived from Brucea ferruginea. Its composition was determined by Regnault.i ... 

The convulsant alkaloid strychnine from the Indian tree Strychnos nux vomica is highly toxic. Strychnine... 

Strychnine is a complex lipophilic alkaloid from the plant Strychnos mx-vomica, which acts as a neurotoxin. It has been used to control vertebrate pests, including moles. The acute oral LDjq to the rat is 2 mg/kg. 

Iridoids and their related alkaloids are widely spread in angiosperms and are found in 13 orders and 70 families including Rutales, Buxales, Hamamelidales, Comales, Loasales, Gentianales, etc. Important iridoids are loganin, found in high amounts in Strychnos nux-vomica and in Catharanthus roseus, and secologanin found especially in Caprifoliaceae. 

The alkaloid normelionine-B (25) has been isolated from the root bark of Strychnos nux-vomica L. (30) however, its structure has not been established completely. The relative steric positions of hydrogens attached to the C-3, C-15, and C-20 stereo centers are assumed to be a,a,(3 or a,a,a, respectively. 

Spring, F. S., H. R. Bentley, J. A. Henry and D. S. Irvine Triterpene Resinols and Related Acids. Part XXVIII. The Non-saponificable Fraction from Strychnos nux-vomica Seed Fat The Structure of cyclo-Artcnol. J. chem. Soc. [London] 1953, 3673. 

As reviewed by Ujvary some of the earliest natural product-based pesticides were those for the elimination of vertebrate pests. For example, strychnine (Fig. 19), obtained from seeds of Strychnos nux-vomica, is a rodenticide that is an antagonist to the neurotransmitter glycine and is used against a few mammal species, as well as pest birds and fish. The first generation of anticoagulant rodenticides were based on dicoumarin. 

Frederich, M., Choi, Y. H. and Verpoorte, R. 2003. Quantitative analysis of strychnine and brucine in Strychnos nux-vomica using H-NMR. Planta Medica, 69 1169-1171. 

Strychnos nux-vomica L. Fan Mu Pen (Strychnine) (seed) Strychnine, monomeric tertiary indole alkaloids, brucine.50 144-504 This herb is highly toxic. Treat neurasthenia, aphrodisiac, vasomotor stimulation, regulate blood pressure, treat nerve diseases. 

Eupatorium formosanum Salvia miltiorhiza Oxyria digyna Artocarpus heterophyllus Clivia miniata Mimosa invisa, M. pudica Acacia catechu Elephantopus molis Crotalaria sessiliflora Strychnos nwc-vomica... 

Xanthium chinense, X. japonicum, X. mongolicum, X sibiricum, X. strumarium Strychnos nux-vomica, S. pierriana... 

Digitalia purpurea, Hypericum perforatum, Matteuccia struthiopteris, Plantago major, Strychnos nux-vomica... 

Rauvolfia serpentina, Strychnos nux-vomica Cannabis sativa... 

Lobelia inflata Strychnos nux-vomica Humulus lupulus... 

Matteuccia struthiopteris, Melochia tomentosa, Rehmannia glutinosa, Scutellaria baicalensis, S. macrantha, S. lateriflora, Urtica urens Strychnos nux-vomica Quercus robur... 

Strychnos nux-vomica mannose and galactose identified, but no ratios given 91... 

Asian Strychnos nux-vomica and Strychnos (-)-Strychnine (1) ignatti.6 Extensive degradative and structural FIGURE 1... 

Sukul NC, Ghosh S, Sinhababu SP. 1998. High dilution effects of Strychnos nux-vomica L on hypothalamic neurons and adrenergic nerve endings of alcoholic rats. In High dilution effects on cells and integrated systems. C Taddei-Ferretti and P Marotta (Eds). World Scientific, Singapore, pp 218-223. 

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