Melochia tomentosa

N.A. Melochia tomentosa L. Melovinone, melosatin D, stigmasterol, beta-sitosterol, beta-sitosterol, beta-D-glucoside, octacosanol.336327 Tumourigenic properties. 

Kapadia, G. J., Y. N. Shuykla, and S. P. Basak. 1978. Melovinone, an open chain analogue of melochinone from Melochia tomentosa. Phytochemistry 17 1444-1445. 

Kapadia, G. J. and Y. N. Shukla. 1993. Ju899Melosatin D a new isatin alkaloid from Melochia tomentosa roots. Plants Med. 59 568-569. 

Camellia sinensis, Crocus sativus, Prunus mume Melochia tomentosa Campanula rotundifolia, C. palustris Hedera helix... 

Alnus crispus,A. glutinosa, Anemone pulsatilla, Cassia angustifolia, C. senna, Corylus avellana, C. cornuta, C. rostrata, C. americana, Lycium barbarum, L. chinense, L. pallidum, Matteuccia struthiopteris, Melochia tomentosa, Paeonia lactiflora, Rehmannia glutinosa, Scutellaria baicalensis, S. macrantha,... 

Melia azedarach Melochia tomentosa Melochia tomentosa... 

Matteuccia struthiopteris, Melochia tomentosa, Rehmannia glutinosa, Scutellaria baicalensis, S. macrantha, S. lateriflora, Urtica urens Strychnos nux-vomica Quercus robur... 

Details of the structure elucidation of melosatins A (4) and B (5)10 have now been published 110 melosatin C, a new metabolite from Melochia tomentosa L., is the closely related 4-(5-phenylpentyl)isatin derivative (6). 

H. perforatum Melicope leratii Melochia tomentosa Ruta chalepensis... 

The unusual tricyclic 3-methoxy-4-quinolone (10) was obtained recently from Melochia tomentosa (cf. Vol. 7, p. 82) and a structurally related alkaloid, melovinone (9), has now been isolated from the same source.The constitution of melovinone was elucidated by spectroscopic studies. 

The constituents of the tumorigenic plant Melochia tomentosa include 6-methoxy-7,8-methylenedioxycoumarin, three cyclopeptide alkaloids, melo-chinone (a quinolinone derivative), and two novel phenylpentyl-isatins, melosatins A and B, for which the structures (3) and (4) have been deduced. The structure of melosatin A was confirmed by synthesis (Scheme 1),... 

Scutianine-B (70) Discaria febrifuga (sb), Melochia tomentosa (r), Scutia buxifolia (r, sb)... 

The roots of Melochia tomentosa (Sterculiaceae), which grows wild in the tropics, are used as an antiinflammatory for the throat in traditional medicine, and melochinone vas isolated from the roots of this plant. The chemical structure was determined by x-ray crystallography and it was found that this alkaloid possesses a 7-membered ring and a benzene ring, as well as a quinoline moiety [Ij.The chemical shift ( H NMR) of the methylene moiety of the 7-membered ring attached to the quinoHne moiety was shifted to lower field at 83.56 ( H, t), probably because of the proximate carbonyl moiety. 

Melochia tomentosa, a tumorigenic plant of the Sterculia-ceae, has been shown to contain the alkaloids melosatin A and B (44, 45) that contain an indole nucleus and are quite unusual in stracture (Kapadia et al., 1977). 

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