Acids, and Related

Hydroxy- and cpoxyalkyl-phosphonic and phosphinic acids, and related sulphur or selenium co/npou/jt/s-Conventional reactions between 1,2-propadienylphosphinic acid and substituted benzaldehydes yield [(a-hydroxybenzyl)( 1,2-propadienyl)]phosphinic acids. Reactions between (1-oxoalkyl)pho.sphonic esters and nitromethane in the pre.sence of a base (K2CO3) yield the esters (281). The compounds (282 n = 1 or 2), and (283) are obtainable conventionally from the cyclic ketone and dimethyl [Pg.149]

Mixtures containing A -methyl-4-piperidone, a dialkyl hydrogen phosphonate and a 3-amino-1-propyne afford the two product types (287) and (288), the former predominating irrespective of the order of mixing of reactants. Conventional reactions between 3-formyl-4-chromone and dialkyl or trialkyl phosphites yield the expected dialkyl ( -hydroxymethyl)-or (a-alkoxymethyl)-phosphonates. [Pg.151]

Normally, dialkyl hydrogen phosphonates act upon 1,4-diketones only at the more reactive carbonyl group and successive additions to each carbonyl group do not occur [Pg.151]

Exceptionally, when R = R = Ph, and R = R = H, cyclization of the initial monoadduct to the C-phosphorylated tetrahydrofuran (291) and formation of the double addition product (292) both occur. On the other hand, bis(trimethylsilyl) phosphonite adds to (293) to give both the double addition product (294)(as its bis(trimethylsilyl) [Pg.151]

When hypophosphorous acid adds to the 1,4-diketones (296), the course of the reaction evidently depends, to some extent, on the nature of the group R, and the product types (297) and (298) are each isolable. [Pg.151]

Sterculic acid and related substances are the subject of an article in the July 1982 is sue of Journal of Chemical Education (pp 539-543)... [Pg.200]

Miller, KE. Rich, D.H. Molecular Mechanics Calculations of Cyclosporin A Analogues. Effect of Chirality and Degree of Substitution on the Side-Chain Conformations of (2s, 3r, 4r, 6e)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoic Acid and Related Derivatives. [Pg.54]

SALICYLIC ACID AND RELATED COMPOUNDS] (Vol 21) l-Acetamido-2-pyrrolidinone [7491-74-9]... [Pg.4]