Structure tissue specificity

Li, E, Demmer, L. A., Sweetser, D. A, Ong, D E., and Gordon, J. I (1986) Rat cellular retinoI-binding protein-II—use of a cloned cDNA to define its primary structure, tissue-specific expression, and developmental regulation Proc. Natl Acad. Sci USA 83, 5779-5783. 

Figure 37-14. Alternative promoter use in the liver and pancreatic B cell glucokinase genes. Differential regulation of the glucokinase GK) gene is accomplished by the use of tissue-specific promoters. The B cell GK gene promoter and exon 1B are located about 30 kbp upstream from the liver promoter and exon 1L. Each promoter has a unique structure and is regulated differently. Exons 2-10 are identical in the two genes, and the GK proteins encoded by the liver and B cell mRNAs have identical kinetic properties.

NRTls are structural analogues of the natural nucleotides that form the building blocks of RNA and DNA in human cells. Their use as part of HAART has dramatically modified the natural history of HIV infection. They, however, cause a range of drag- or tissue-specific toxicides zidovudine (AZT) causes myopathy zalcitabine (ddC), didanosine (ddl), and lamivudine (3TC) cause neuropathy stavudine (d4T) causes neuropathy or myopathy and lactic acidosis (Dalakas 2001). During phase 1 and 11 trials, the dose-limiting toxicity of didanosine, zalcitabine, and stavudine was identified as peripheral neuropathy (Dalakas 2001). 

Freshour G., R. P. Clay, M. S. Fuller, P. Albersheim, A. Darvill and M. G. Hahn. (1995). Developmental and tissue-specific structural alterations of the cell wall poysaccharides of Arabidopsis thaliana roots. Plant Physiology 110 1413-1429. 

Repetitive overuse of a tendon can cause cellular changes in the tissues. Specifically, collagenous tendon tissue is replaced with tissue that lacks the longitudinal structure of a normal tendon.16 As a result, the tendon progressively loses elasticity and its ability to handle stress or weight. This makes the tendon vulnerable to rupture or inflammation (tendonitis and tenosynovitis). 

Paules, R. S., Propst, F Dunn, K. J., Blair, D. G., Kaul, K., Palmer, A. E., and Vande Woude, G. F. (1988). Primate c-mos proto-oncogene structure and expression transcription initiation both upstream and within the gene in a tissue-specific manner. Oncogene 3 59-68. 

Gould GW, Holman GD. The glucose transporter family structure, function and tissue specific expression. Biochem J 1993 295 329-341. 

These organelles occur in the endosperm of cereal grains and their structures are tissue specific. They are about 2-5 im in diameter and often contain globoid and occasionally crystalloid inclusions. Prolamin accumulates in small or large spherical bodies. Crystalline protein bodies are the sites of accumulation of nonprolamin storage proteins. 

As with the DE lines, the CC lines give an indication about the level of characterization of a protein. The example provides experimentally verified information about the "function", the quatenary structure ("SUBUNIT"), the "SUBCELLULAR LOCATION" and the "TISSUE SPECIFICITY" of the protein. A description of the "disease (s) " known to be associated with a deficiency of the protein, a description of the "SIMILARITY" of the protein with other proteins, and a cross reference to network "DATABASE" resource(s) for this specific protein are also found. 

Description of subcellular location of mature protein Description of quaternary structure of a protein Description of tissue specificity of a protein... 

The bisindole alkaloids are clearly closely associated with MDR from both historical and structural perspectives. The clinical relevance of this mechanism of drug resistance has not been unambiguously established however, the tissue-specific expression of P-gp has been noted for several normal as well as malignant tissues (105). Therefore, the natural resis-... 

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