Structural DNA

Due to its unique chemical composition and structure, DNA can interact with a plethora of chemical structures via numerous types of bonds. This property ultimately defines the ability of DNA fragments to serve as the building blocks in the complex three-dimensional self-assembled structures. Following we Ust four major types of polymer/DNA interactions that can lead to formation of supramolecular structures ... 

Under a variety of conditions, plasmid DNA undergoes a dramatic compaction in the presence of condensing agents such as multivalent cations and cationic polymers. Naked DNA coils, typically with a hydrodynamic size of hundreds of nanometers, after condensation it may become only tens of nanometer in size. Contrary to proteins which show a unique tertiary structure, DNA coils do not condense into unique compact structure. Cationic polymers execute their gene carrier function by their condensation effect on gene materials and, furthermore, their protection effect on DNA from nuclease digestion. Currently, the most widely used cationic polymers in research include linear or branched PEI (poly (ethyleneimine) (161-165), polypeptides such as PLL (poly-L-lysine) (166-169), PLA (poly-L-arginine) (170). 

Tie began working with Francis Crick in 1950 at the Cavendish laboratories. Ill 1953, Watson and Crick, using the photographs of Rosalind Franklin, which exposed crystallized molecules from the nucleus, identified the material that biologists were viewing in the nucleus as DNA. Watson and Crick created a three-dimensional structure DNA model, which provided scientists with a valuable tool in the study of heredity. In 1962 Watson-Crick were awarded the Nobel Prize for their work. 

Patra AK, Nethaji M, Chakravarty AR. Synthesis, crystal structure, DNA binding and photo-induced DNA cleavage activity of (.S -mcthyl-r.-cystcinc)coppcr(II) complexes of heterocyclic bases. J Inorg Biochem 2007 101 233-44. 

Builds and plots 3D structures. DNA/RNA Builder. Protein Predictor and N.N.Charge both based on neutral network approach. Macintosh. 

Taxonomy of Known Viral Structure DNA Genome, Single Stranded"... 

Chromosome structure, DNA topoisomerases, and DNA polymerases in archaebacteria (archaea)... 

Bonnet, G., Tyagi, S., Libchaber, A., and Kramer, F.R. Thermodynamic basis of the enhanced specificity of structured DNA probes. Proc. Natl. Acad. Sci. USA, 96, 6171-6176, 1999. 

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