Structure of DNA Duplexes with Mismatched Base Pairs

5 Structure of DNA Duplexes with Mismatched Base Pairs 

Faithful transmission of genetic information depends on the correct insertion of bases during replication, proofreading by DNA polymerases and the excision of misinserted bases. In addition to mutations induced by mismatches during replication, chemical agents, heat and UV radiation can damage DNA. Heat can cause 

The finding that the global conformations of duplexes with mismatched base pairs are practically identical with those of normal ones limits the structural differences 

T- structures of mispaired oligonucleotides. The deLnfr,rotonaX wk mismatch with cytosine protonated (b), the C-A mismatch with 

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