Gene carriers

Matsumoto Y, Itaka K, Yamasoba T, Kataoka K (2009) Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers. J Gene Med 11 615-623... [Pg.29]

Rnorr V, Russ V, Allmendinger L, Ogris M, Wagner E (2008) Acetal linked oligoethy-lenimines for use as pH-sensitive gene carriers. Bioconjug Chem 19 1625-1634... [Pg.29]

This question revolves around the delivery tools for the genes. The transport system or vehicles used are called vectors (gene carriers). There are two basic gene therapy techniques in vitro and in situ methods. [Pg.124]

Huang Z, et al. Thiocholesterol-based lipids for ordered assembly of biorespon-sive gene carriers. Mol Ther 2005 11 409. [Pg.125]

The penetrance of Marian mutations is high, so it is highly unlikely that all other gene carriers in the femily would be nonpenetrant carriers (choice B). [Pg.297]

Chromosome Hie heredity-bearing gene carrier situated within the cell nucleus and composed of DNA and protein. [Pg.226]

Under a variety of conditions, plasmid DNA undergoes a dramatic compaction in the presence of condensing agents such as multivalent cations and cationic polymers. Naked DNA coils, typically with a hydrodynamic size of hundreds of nanometers, after condensation it may become only tens of nanometer in size. Contrary to proteins which show a unique tertiary structure, DNA coils do not condense into unique compact structure. Cationic polymers execute their gene carrier function by their condensation effect on gene materials and, furthermore, their protection effect on DNA from nuclease digestion. Currently, the most widely used cationic polymers in research include linear or branched PEI (poly (ethyleneimine) (161-165), polypeptides such as PLL (poly-L-lysine) (166-169), PLA (poly-L-arginine) (170). [Pg.353]

Vierling, P., Santaella, C. and Greiner, J. (2001) Highly fluorinated amphiphiles as drug and gene carrier and delivery systems. J. Fluorine Chem., 107, 337-354. [Pg.303]

Lee H, Williams SK, Allison SD, Anchordoquy TJ (2001) Analysis of self-assembled cationic lipid-DNA gene carrier complexes using flow field-flow fractionation and light scattering. Anal Chem 73(4) 837-843... [Pg.13]

Lin AJ, Slack NL, Ahmad A et al (2003) Three-dimensional imaging of lipid gene-carriers membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes. Biophys J 84 3307-3316... [Pg.91]

This review deals with the syntheses of various hyperbranched polyamines that are prepared through a one-step polymerization process. Furthermore, we present the current status of polyamines as gene carriers and describe their versatility, and their properties such as structure-property dependency, gene transfection efficiency, and cytotoxicity profiles of hyperbranched polyamines. [Pg.95]

Mao H-Q (2001) Chitosan-DNA nanoparticles as gene carriers synthesis, characterization and transfection efficiency. J Control Release 70(3) 399—421... [Pg.185]

Jiang H-L, Kim Y-K, Arote R et al (2007) Chitosan-graft-polyethylenimine as a gene carrier. J Control Release 117 273-280... [Pg.186]

Kim T-H, Jiang H-L, Jere D et al (2007) Chemical modification of chitosan as a gene carrier in vitro and in vivo. Prog Polym Sci 32(7) 726-753... [Pg.186]

Jiang H, Kwon J, Kim Y et al (2007) Galactosylated chitosan-graft-polyethylenimine as a gene carrier for hepatocyte targeting. Gene Ther 14(19) 1389-1398... [Pg.186]

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