DNA structure-function relationship

Hole, E.O. Sagstuen, E. Close, D.M. Nelson, W.H. In Radiation Damage in DNA Structure Function Relationships at Early times, Fucianelli, A.F. Zimbrick, J.D., Eds. Battelle Press Columbus, Ohio, 1995 105 pp. 

Fuciarelli AF, Zimbrick JD (eds) (1995) Radiation Damage in DNA Structure/Function Relationships at Early Times, Batelle, Columbus. 

RNA structures, compared to the helical motifs that dominate DNA, are quite diverse, assuming various loop conformations in addition to helical structures. This diversity allows RNA molecules to assume a wide variety of tertiary structures with many biological functions beyond the storage and propagation of the genetic code. Examples include transfer RNA, which is involved in the translation of mRNA into proteins, the RNA components of ribosomes, the translation machinery, and catalytic RNA molecules. In addition, it is now known that secondary and tertiary elements of mRNA can act to regulate the translation of its own primary sequence. Such diversity makes RNA a prime area for the study of structure-function relationships to which computational approaches can make a significant contribution. 

A cloned complementary DNA to a neurotoxin precursor RNA extracted from the venom glands of Laticauda semifasciata was isolated and its nucleotide sequence was identified 11). The cloning of neurotoxin should aid the understanding of structure—function relationship eventually. 

Braun CS, Vetro JA, Tomalia DA et al (2005) Structure/function relationships of polyami-doamine/DNA dendrimers as gene delivery vehicles. J Pharm Sci 94(2)423 136... 

Tomasselli, A.G., Heinrickson, R.L., and Watenpaugh, K.D. (1991). Recombinant DNA technology and crystaUography a new alliance in unraveling protein structure-function relationships. In Purification and Analysis of Recombinant Proteins. R.Seetharam and S.K.Sharma, eds. (New York Marcel Dekker), pp. 285 315. 

In contrast to rational design methods, where changes in protein properties may be predicted from sequence changes, random mutation methods have been introduced to empirically improve protein properties in the absence of a priori knowledge of structure-function relationships. Error-prone polymerase chain reaction (PCR), for example, can be used to introduce approximately random mutations in amplified DNA sequences. The protein products of these mutations may then be screened to select successful or improved variants.2... 

Broyde, S., Wang, L., Zhang, L., Rechkoblit, O., Geacintov, N.E., and Patel, D.J. (2008) DNA adduct structure-function relationships comparing solution with polymerase structures. Chem. Res. Toxicol, 21, 45-52. 

Multidisciplinary Approach Towards Investigating Structure-Function Relationships in the NER of Bulky PAH-DNA Adducts... 

Elucidating Structure-Function Relationships in Bulky DNA Lesions From Solution Structures to Polymerases... 

DNA Polymerase Structure-Function Relationships Elucidated with B[a]P-Derived Lesions 335... 

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