Relationships between the Chemical, Structural, and Biological Features of DNA Lesions

Relationships between the Chemical, Structural, and Biological Features of DNA Lesions 

Molecular dynamic simulation methods, in addition to being essential for interpreting NMR data at the atomic level, also augment experimental studies in a number of other ways [101] modeling techniques can (i) yield structural information where experimental data has not yet been acquired, (ii) expand on experimental data through simulations that yield dynamic trajectories whose analysis provides unique information on lesion mobility, and (iii) provide thermodynamic insights by ensemble analysis using statistical mechanical methods. Furthermore, reaction mechanisms can now be determined with some confidence by combined quantum mechanical and molecular mechanical methods [104, 105], 

Part One of the book, entitled Chemistry and Biology of DNA Lesions, will introduce the reader to the fundamentals of the chemical characterization, biochemical 

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