Stem cells differentiation induction

Olivares-Navarrete R, et al. Direct and indirect effects of microstructured titanium substrates on the induction of mesench3mial stem cell differentiation towards the osteoblast lineage. Biomaterials 2010 31(10) 2728—35. 

Quassinoids have attracted much attention due to the wide spectrum of biological activities that they display, viz., antimalarial, antifeedant, anti-inflanunatory, antiulcer, antipyretic, antifertility, antileukemic, cytotoxic activities, and induction of murine stem cell differentiation which have been widely reported [54-59]. We have demonstrated that quassin is a potent immunomodulatory tool that efficiently controls the estabhshment of leishmanial parasite within the host macrophages [60]. Our contention was that quassin could be used as a potential inununomodulator to generate the required immunity not only for the treatment of leishmaniasis but also for the treatment of other chronic infectious diseases. Subsequently, we had shown that both quassin and neoquassin can be used along with artesunate (a derivative of artemisinin) as combinatorial therapy against malaria [61]. 

LaRosa, G. J. and Gudas, L J. (1988) An early effect of retinoic acid, cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation. Proc. Nat Acad Sci. USA 85, 329-333. 

Sachlos, E. and Auguste, D. T. 2008. Embryoid body morphology influences diffusive transport of inductive biochemicals A strategy for stem cell differentiation. Biomaterials 29(34) 4471-80. 

Schmitt, T. M., De Footer, R. R, Gronski, M. A. et al. 2004. Induction of t cell development and establishment of t cell competence from embryonic stem cells differentiated in vitro. Nat Immunol 5(4) 410-7. 

Neuss and coworkers have reported the possibility of SMPs using PCL dimethacrylate copolymers as cellular scaffold for tissue engineering. Behaviors of different cells from three different species (human mesenchymal stem cells, human mesothelial cells, and rat mesothelial cells) on the matrices were investigated, and the differentiation capacity of mesenchymal stem cells on the matrices was also analyzed [329]. The SMPs proved biocompatibility for all tested cell types, supporting viability and proliferation. The SMPs also supported the osteogenic and adipogenic differentiation of human mesenchymal stem cells 3 weeks after induction. 

Ying QL, et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. CeU 2003 115 281-292. 

RGD-peptide, which is the classic integrin ligand (73). The cells spread on RGD presenting membranes but not on control membranes that lacked this peptide. In a similar approach, a laminin-derived peptide was presented on supported bilayers and shown to mediate the spreading and partial differentiation of neuronal subventricular zone progenitor cells (74). The authors observed a strong nonlinear relationship between surface concentrations of the peptides and conclude that this approach may provide novel conditions for growing stem cells with only a limited and controlled amount of differentiation induction. 

Strickland S, Mahdavi V. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 1978 15 393-403. 

Rathjen, P.D., Nichols, J., Toth, S., Edwards, D. R., Heath, J.K. and Smith, A.G. (1990a) Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations. Genes Dev. 4 2308-2318. 

Niwa H, Miyazaki J, Smith A G (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 372-376. Chambers I, Colby D, Robertson M, et al. (2003). Eunctional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 113 643-655. Ying Q L, Nichols J, Chambers I, et al. (2003). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell. 115 281-292. 

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