Squamous cell head and neck cancer

Gonzalez-Larriba J, Garcia Carbonero I, Sastre Valera J, Perez Segura P, Diaz-Rubino E. Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer. Oncology (Huntingtj 1997 11(9 Suppl 10) 90-97. 

Adelstein DJ, Sharan VM, Earle AS, et al. Long-term results after chemoradiotherapy for locally confined squamous-cell head and neck cancer. Amer J Clin Oncol 1990 13 440-447. 

Adelstein DJ, Saxton JP, Lavertu P, et al. A phase III trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer preliminary results. Head Neck 1997 19 567-573. 

A preliminary report on a randomized trial on 83 stage III or IV locally advanced squamous cell head and neck cancer (SCHNC) patients demonstrated improved 2-yr disease-free survival (65% vs 41%, p = 0.01) and increased rate of local control (85% vs 59%, p < 0.05) in the concomitant chemoradiation group (cisplatin 50 mg/m2 weekly) in comparison to radiation therapy alone (25). It should be noted that the DFS was improved overall in the concomitant arm despite 18% patients receiving only two-thirds of their scheduled dose of cisplatin as a result of nausea and vomiting. Mature results from this study have not been published to date. 

Adelstein DJ, Adams GL, Li Y. A phase III comparison of standard radiation therapy (RT) versus RT plus concurrent cisplatin (DDP) versus split-course RT plus concurrent DDP and 5-fluorouracil (5FU) in patients with unresectable squamous cell head and neck cancer (SCHNC), ProcAnnu Meet Am Soc Clin Oncol 2000 19 A 1624. 

Brizel DM, Wasserman TH, Henke M et al. (2000) Phase 111 randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18 3339-3345 Brizel DM (ed) (2005) Strategies for protecting normal tissue in the treatment of head and neck cancer. In Adelstein DJ, ed Squamous Cell Head and Neck Cancer Recent Clinical Progress and Prospects for the Future. Totowa, NJ, Humana Press, pp 228... 

Suwinski R, Bankowska-Wozniak M, Majewski W, et al (2008) Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer. Radiother Oncol 87 155-163 Thames HD, Ruifrok AC, Milas L, et al (1996) Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma downregulation of apoptosis as a possible mechanism. Int J Radial Oncol Biol Phys 35 951-962 Trott KR, Kummermehr J (1991) Rapid repopulation in radiotherapy a debate on mechanism. Accelerated repopulation in tumours and normal tissues. Radiother Oncol 22 159-160... 

Marcial VA, Paj ak TF, Mohuiddin M, et al. ConComitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Cancer 1990 66 1861-1868. 

Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000 ... 

Suntharalingam M, Haas ML, Van Echo DA, et al. Predictors of response and survival after concurrent chemotherapy and radiation for locally advanced squamous cell carcinomas of the head and neck. Cancer 2001 91(3) 548-554. 

Leonard CE, Chan DC, Chou TC, et al. Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck. Cancer Res 1996 56 5198-5204. 

Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999 59 1935-1940. 

Ensley JF, Jacobs JR, Weaver A, et al. Correlation between response to cis-platinum combination and subsequent radiotherapy in previously untreated patients with advanced squamous cell cancers of the head and neck. Cancer 1984 54 811-814. 

Tumor-selective destruction has been observed in squamous cell carcinoma patients treated with chemotherapy plus Onyx-015. But, when the virus was given alone, it produced a clinical response in less than 15% of patients. A multinational team of researchers has shown in a phase II trial of Onyx-015 with chemotherapy that the combined treatment was more effective than either therapy alone in patients with recurrent head and neck cancers [4]. 

Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol. 2001 13(3) 183-188. 

Somers KD, Merrick MA, Lopez ME, Incognito LS, Schechter GL, Casey G (1992) Frequent p53 mutations in head and neck cancer. Cancer Res 52 5997-6000 Stephenson TJ, Royds J, Silcocks PB, Bleehen SS (1992) Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma. Br J Dermatol 127 566-570 Suzuki T, Ueda M, Kazuhiro N, Tohru N, Harada S, Imaizumi K, Watanabe S, Ichihashi M (1997) Incidence of actinic keratosis of Japanese in Kasai City, Hyogo. J Dermatol Sci 16 74-78... 

The accessibility of primary and metastatic squamous cell carcinomas (SCC) of the head and neck for tumor oxygenation assessment has meant that these tumors have received considerable attention with a large number of studies already documented (see Table 4.5). Reliable Oj-sensitive polarographic electrodes for measurement of O2 tensions in head and neck cancers were first used by Gatenby et al. (1985,1988). These authors convincingly demonstrated that hypoxia in advanced tumors was associated with a poor prognosis. 

Stadler P, Becker A, Feldmann HJ et al (1999) Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. Int J Radiat Oncol Biol Phys 44 749-754 Stadler P, Feldmann HJ, Creighton C et al (2000) Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck. Int J Biol Markers 15 235 236... 

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