Tumor oxygenation

Brizel DM, Rosner GL, Prosnitz LR, et al. Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. Int J Radiat Oncol Biol Phys 1995 Jul 15 32(4) 1121—1125. 

Experiments in which tumor xenografts were treated with paclitaxel and radiation in hypoxic and noroxic conditions were pursued (46). It was found that the creation of hypoxic conditions greatly reduced the efficacy of paclitaxel in its enhancement of radioresponse. Measurements of tumor oxygenation using Eppendorf histographs confirmed that the median tumor P02 increased from the control value of 6.8 mmHg to... 

C. Baudelet, B. Gallez, Current issues in the utility of blood oxygen level dependent MRI for the assessment of modulations in tumor oxygenation, Curr. Med. Imag. Rev. 1 (2005) 229-243. 

D. Zhao, L. Jiang, R.P. Mason, Measuring changes in tumor oxygenation, Meth. Enzymol. 386 (2004) 378 18. 

R.P. Mason, S. Ran, P.E. Thorpe, Quantitative assessment of tumor oxygen dynamics Molecular Imaging for Prognostic Radiology, J. Cell. Biochem. 87(Suppl.) (2002) 45-53. 

Y. Gu, V. Bourke, J.G. Kim, A. Constantinescu, R.P. Mason, H. Liu, Dynamic response of breast tumor oxygenation to hyperoxic respiratory challenge monitored with three oxygen-sensitive parameters, Appl. Opt. 42 (2003) 1-8. 

B. Gallez, C. Baudelet, B.F. Jordan, Assessment of tumor oxygenation by electron paramagnetic resonance Principles and applications, NMR Biomed. 17 (2004) 240-262. 

D. Zhao, A. Constantinescu, C.H. Chang, E.W. Hahn, R.P. Mason, Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor, Radiat. Res. 159 (2003) 621-631. 

Z. Wang, M.Y. Su, O. Nalcioglu, Applications of dynamic contrast enhanced MRI in oncology Measurement of tumor oxygen tension, Technol. Cancer Res. Treat. 1 (2002) 29-38. 

R.P. Mason, P.P. Antich, Tumor oxygen tension Measurement using OxygenF as a F NMR probe at 4.7 T, Artif. Cells Blood Substit. Immobil. Biotechnol. 22 (1994) 1361-1367. 

R.P. Mason, P.P. Antich, E.E. Babcock, A. Constantinescu, P. Peschke, E.W. Hahn, Non-invasive determination of tumor oxygen tension and local variation with growth, Int. J. Radiat. Oncol. Biol. Phys. 29 (1994) 95-103. 

X. Fan, J.N. River, M. Zamora, H.A. Al-Hallaq, G.S. Karczmar, Effect of carbogen on tumor oxygenation Combined fluorlne-19 and proton MRI measurements, Int. J. Radlat. Oncol. Biol. Phys. 54 (2002) 1202-1209. 

P.S. Hees, C.H. Sotak, Assessment of changes In murine tumor oxygenation in response to nicotinamide using F NMR relaxometry of a perfluorocarbon emulsion, Magn. Reson. Med. 29 (1993) 303-310and erratum 329 716 (1993). 

Increased tumor oxygenation actually reduces hypoxia-regulated VEGF levels and consequently tumor angiogenesis... 

Nordsmark M, Bentzen SM, Rndat V et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005 77(1) 18-24. 

Tumor oxygenation was the topic of work published by Hull et al. [157]. In this paper, they showed detectable shifts toward higher saturation in all tumors. These hemoglobin changes were induced by introduction of carbogen. The new hemoglobin saturation levels were reached within a minute and remained constant throughout the experiment. 

At present, there is usually a 15-minute equilibration period of the patient with oxygen prior to irradiation. In the future, pressures greater than 3 or 4 ata may have to be employed to assure adequate tumor oxygenation, and confirmation of the degree of oxygenation by micropolarographic electrodes may be required. Ultimately, such measurements would control the degree of pressurization required for each specific tumor to be irradiated. 

Because of the increased sensitivity of tumors to X-irradiation therapy in the presence of increased tumor oxygen tension, and because nitrogen mustard has an effect on tumors similar to that of ionizing radiation, some investigators have postulated that the tumoricidal effect of csrtotoxic drugs... 

Sersa G, Krzic M, Sentjurc M, et al Reduced tumor oxygenation by treatment with vinblastine. Cancer... 

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