Dosing schedule

Each of the transdermal nitroglycerin systems is effective in treating angina pectoris when worn for 12—16 h followed by an off period. The FDA recommends the period without dmg (8—12 h) to mitigate the possibiUty of the patient acquiring a tolerance to the antianginal effects of nitrate therapy. Thus, a noncontinuous dosing schedule of nitrates is recommended even with the transdermal deflvery system (81). 

Usual dose schedules of streptozotocin involve 500 mg/m2 i.v. during five consecutive days. The major toxicity is renal tubular damage. Treatment of metastatic insulinomas may result in the release of insulin from the tumor and subsequent hypoglycemic coma. Less severe toxicities include diarrhea, anemia, and mild alterations in glucose tolerance or liver function tests. 

The following isa suggested dosing schedule for the administration of midodrine shortly before arising in the morning, midday, and late afternoon (not after 6 00 fm). The nurse should continue drug therapy only in the patient whose orthostatic hypotension improves during the initial treatment. 

LAAM usually has been prescribed in doses of 20—140 mg (Ling et al. 1978 Tennant et al. 1986). The typical Monday-Wednesday-Friday dosing schedule is 100 mg—100 mg—140 mg. The maximum recommended doses are 140 mg—140 mg—140 mg or 130 mg—130 mg—180 mg (thrice-weekly schedule) or 140 mg every other day. For some patients LAAM holds better than methadone. There is evidence that LAAM may be particularly helpful for patients who do not respond to high-dose methadone because of low plasma levels (Tennant 1988). Others patients prefer LAAM to methadone because they can attend the clinic less often (Tennant et al. 1986 Trueblood et al. 1978). However, a few experience nervousness and stimulation while taking this drug. 

Transdermal nicotine is available in a variety of formulations and dosing schedules (e.g., 15 mg/l6 hours 7, 14, and 21 mg/24 hours and 11 and 22 mg/ 24 hours) (Cinciprinni and McClure 1998). Peak nicotine concentrations for the various systems are reached 2-6 hours after application, and steady state conditions occur 2—3 days after continued patch use (Henningfield 1995). The highest-dose patch (i.e., 21 or 22 mg/24 hours or 15 mg/l6 hours) delivers approximately 0.9 mg of nicotine per hour transdermally (Henningfield... 

Janah S, Hussain QZ, Chaudhuri SN. 1970. Effect of hydrocortisone on immune cytokinetics. Part 1-Effects of different dose schedules on 19S and 7S antibody forming cells in Jeme s plaque technique. Indian J Med Res 58 1206-1216. 

Within a given animal species, in addition, the selection of target organs, at least under certain dosing schedules, may also be an explicit function of molecular structure. 

Cumulative dosing schedules are useful and have practical application in psychopharmacology (Wenger 1980). The use of the cumulative IV dosing schedule in these studies permitted the full range of activities for each compound to be observed in a group of animals in one test session. 

Product Recipient Age (Years) Dose Volume (mL) No. of Doses Schedule (Months)... 

Symptomatic treatment focuses on minimizing the withdrawal symptoms to help patients be as comfortable as possible (Tables 33-6 through 33-8). This is combined with the use of methadone or buprenorphine (Suboxone or Subutex ) to suppress the withdrawal symptoms by providing a p opioid full or partial agonist in a tapering dose schedule within a controlled environment. 

Stimulants should be initiated at recommended starting doses and titrated up with a consistent dosing schedule to the appropriate response while minimizing side effects (Table 39-2). Generally, stimulants should not be used in patients who have glaucoma, severe hypertension or cardiovascular disease, hyperthyroidism, severe anxiety, or previous illicit or stimulant drug abuse. Further, stimulants can be used, albeit cautiously, in patients with seizure disorders, Tourette s syndrome, and motor tics.14... 

The dose of basiliximab is 20 mg intravenously (IV) given within 2 hours prior to the transplant, followed by a second 20 mg dose on postoperative day 4.7,9,11 This dosing schedule can be used for both children weighing 35 kg (77 lb) or more and adults. Two 10 mg doses with the same dosing schedule should be used for children weighing less than 35 kg (77 lb). No specific dosage adjustments is needed in renal or hepatic impairment.7,9,11... 

Based on the information provided, what are the goals of therapy for this patient Select and recommend a therapeutic plan for treatment of this patient s TB infection. What drugs, dose, schedule, and duration of therapy are best for this patient How should any contacts infected by this patient be evaluated and treated Select and recommend a therapeutic plan. What drugs, dose, and schedule of therapy are best for his close contacts ... 

The choices of chemotherapy regimen, dose, schedule, and duration of therapy, as well as the choice of endocrine therapy, are controversial and rapidly changing as results from ongoing randomized clinical trials are reported. 

TABLE 88-2. Dosing Schedules of Chemotherapy Regimens for Colon Cancer3... 

Similar to 5-FU, there is a polymorphism associated with irinotecan toxicity. UDP-glucuronosyltransferase (UGT1A1) is an enzyme responsible for the glucuronidation of SN-38 to inactive metabolites, and reduced or deficient levels of this enzyme correlate with irinotecan-induced diarrhea and neutropenia.39 Recently the FDA approved a blood test that detects variations in this gene. This test will assist health care providers in predicting which patients may develop severe toxicities from normal doses of irinotecan and can be ordered prior to patients receiving irinotecan. binotecan is administered as an IV bolus over 60 to 90 minutes in a variety dosing schedules. 

Several randomized trials have demonstrated that leuprolide and goserelin are effective agents when used alone in patients with advanced prostate cancer.19 Response rates around 80% have been reported, with a lower incidence of adverse effects compared with estrogens.19 There are no direct comparative trials of the currently available LHRH agonists or the dosage formulations, but a recent meta-analysis reported that there is no difference in efficacy or toxicity between leuprolide and goserelin. Therefore, the choice between the two usually is made based on cost and patient and physician preference for a dosing schedule. 

Type of HCT Preparative Regimen Dose/Schedule for Adults... 

Bartlett DW, Davis ME (2008) Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. Biotechnol Bioeng 99 975-985... 

Antibiotic Usual Adult Dose (g) Dose Schedule (doses/day)... 

Unanswered questions with the use of adjuvant trastuzumab include optimal concurrent chemotherapy, optimal dose, schedule and duration of therapy, and use of other concurrent therapeutic modalities. 

Singleantigen vaccine formulations should be administered in a 2-dose schedule at either 0 and 6-12 months (Havrix ), or 0 and 6-18 months (Vaqta ). If the rombined hepatitis A and hepatitis B vaccine (Twinrix ) is used, administer 3 doses at 0,1, and 6 months. 

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