SPECT tomography

Single photon emission computed tomography (SPECT)... 

Single-photon emission computed tomography (SPECT) studies are acquired by rotating the y-camera around the patient s long axis. These data are then used to reconstmct the radioactivity distribution in three dimensions. This may be displayed as sHces of radioactivity concentration or rendered so as to present the appearance of a soHd volume. 

Shaya, E.K., Scheffel, U., Dannals, R.F., Ricaurte, G.A., Carroll, F.I., Wagner, H.N., Jr., Kuhar, M.J., and Wong, D.F., In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55, Synapse, 10, 169, 1992. 

Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Buyens K, Sanders NN, De Smedt SC, Behe M, Kissel T (2009) Stability of siRNA polyplexes from poly(ethylenimine) and poly (ethylenimine)-g-poly(ethylene glycol) under in vivo conditions effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging. J Control Release 138 148-159... 

POSITRON EMISSION TOMOGRAPHY (PET) AND SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) 944... 

Advantages and disadvantages of PET and SPECT. Positron emission tomography. The half-life of the isotopes also makes a difference to their application. 

Finally, newer scanners are being developed with both PET and another modality, such as computed tomography (X-ray CT), where a subject would be scanned first with X-ray CT for anatomy and for attenuation correction, and then imaged for their PET or SPECT measurements. 

DeKosky, S. T., Shih, W. J., Schmitt, F. A et al. Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease correlation with cognitive severity. Alzheimer Dis. Assoc. Disord. 4 14—23,1990. 

The most recent SPECT scan (single photon computed tomography of the brain) studies, by a Harvard School of Public Health physician and researcher, have shown that people with MCS have blood flow patterns in the brain that are different from those of healthy controls and from people with Chronic Fatigue Syndrome.4... 

Scopolamine increases cerebral blood flow to lateral occipital cortex bilaterally and to the left orbitofrontal region (Grasby et al. 1995). Decreases are seen in the right thalamus, precuneus, and lateral premotor areas bilaterally. When normal subjects are chronically administered scopolamine, there is a 12% increase in cerebral blood flow on single photon emission computed tomography (SPECT), but a decrease in cerebral muscarinic binding (Sunderland et al. 1995). On the other hand, acute administration dose-dependently reduces cortical blood flow, which is maximal in frontal cortex (Gitelman and Prohovnik 1992 Prohovnik et al. 1997). 

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