SPECT, Single Photon Emission Computed Tomography

Single photon emission computed tomography (SPECT)... 

Single-photon emission computed tomography (SPECT) studies are acquired by rotating the y-camera around the patient s long axis. These data are then used to reconstmct the radioactivity distribution in three dimensions. This may be displayed as sHces of radioactivity concentration or rendered so as to present the appearance of a soHd volume. 

Shaya, E.K., Scheffel, U., Dannals, R.F., Ricaurte, G.A., Carroll, F.I., Wagner, H.N., Jr., Kuhar, M.J., and Wong, D.F., In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55, Synapse, 10, 169, 1992. 

Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Buyens K, Sanders NN, De Smedt SC, Behe M, Kissel T (2009) Stability of siRNA polyplexes from poly(ethylenimine) and poly (ethylenimine)-g-poly(ethylene glycol) under in vivo conditions effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging. J Control Release 138 148-159... 

POSITRON EMISSION TOMOGRAPHY (PET) AND SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) 944... 

DeKosky, S. T., Shih, W. J., Schmitt, F. A et al. Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease correlation with cognitive severity. Alzheimer Dis. Assoc. Disord. 4 14—23,1990. 

Scopolamine increases cerebral blood flow to lateral occipital cortex bilaterally and to the left orbitofrontal region (Grasby et al. 1995). Decreases are seen in the right thalamus, precuneus, and lateral premotor areas bilaterally. When normal subjects are chronically administered scopolamine, there is a 12% increase in cerebral blood flow on single photon emission computed tomography (SPECT), but a decrease in cerebral muscarinic binding (Sunderland et al. 1995). On the other hand, acute administration dose-dependently reduces cortical blood flow, which is maximal in frontal cortex (Gitelman and Prohovnik 1992 Prohovnik et al. 1997). 

There are now more than 200 PET centres worldwide and, compared to single photon emission computed tomography (SPECT) or magnetic resonance spectroscopy (MRS), PET is the most sensitive technique and gives quantitative data. While there are currently a wide variety of site-specific and F-radio-... 

With single photon emission computed tomography (SPECT), an average difference from normal to abnormal regions of 30-50% is necessary before the abnormality is visually identifiable [17], as opposed to PET where differences of only 5-10% can be visually detected. Moreover, PET has the unique ability to non-invasively quantify relative or absolute coronary blood flow and metabolism... 

Fig. 26. Chemical structure of f llMIBG, a single photon emission computed tomography (SPECT)-radiopharmaceutical for cardiac neuronal imaging, and its lead structure guanethidine.

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