Positron emission tomography compared with SPECT

The kinetic parameters of Tc-HMPAO retention in the human brain have been studied (Lassen et al. 1988), and measurements of CBF have been compared to Xe (Andersen et al. 1988). CBF was quantified using dynamic single-photon emission computer tomography (SPECT) (Murase et al. 1992). The role of SPECT with Tc-HMPAO in ischemic stroke has been evaluated (Heiss 1983 Podreka et al. 1987). Reflow hyperemia in subacute stroke has been described as luxury perfusion (Lassen 1966) and was later explained by hyperfixation of " Tc-HMPAO (Lassen and Sperling 1993). Increased regional blood flow in subacute stroke has been measured with " Tc-HMPAO (Moretti et al. 1990). The effect of acetazolamide on CBF was reported in patients with severe internal carotid artery stenosis/occlusion (Asenbaum et al. 1995), and has been studied in primates (Dormehl et al. 1997). " Tc-HMPAO SPECT was evaluated in patients with cerebrovascular disease by comparison with F-fluoromethane positron emission tomography (PET) (Heiss et al. 1990). A pattern of focal abnormalities in CBF was derived in patients with degenerative dementia (Holman et al. 1992). 

The kinetic parameters of Tc-ECD in the human brain have been compared with regional cerebral blood flow measurements with Xe SPECT (Devous et al. 1993) and with positron emission tomography (PET) (Tsuchida et al. 1992). The response of Tc-ECD, Tc-examethylpropylene amine oxime HMPAO and I-IMP (AT-isopro-pyl-p-[ I]-iodoamphetamine) to changes in cerebral blood flow was studied in primates (Dormehl et al. 1997). 

---