Single photon emission computerized tomography SPECT

The iodinated analogue of A-85380 <1998JME3690>, (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine 241, is a ligand used for single photon emission computerized tomography (SPECT) imaging of human and nonhuman nicotinic acetyl choline receptors in vivo. 

Marijuana can interact with the neurotransmitter dopamine, and the effects of marijuana on the brain in schizophrenia have been studied by single photon emission computerized tomography (SPECT) (84). 

Single photon emission computerized tomography (SPECT) has suggested that some psychiatric symptoms in cocaine users are associated with changes in blood flow (168). Multiple scalloped areas of reduced cerebral blood flow (especially periventricular regions and deep portions of the brain) have been seen. Hypoperfusion has also been noted in the frontal lobes of cocaine users with mania. 

Compounds labeled with isotopes have played an important role in chemistry, biology, and medicine since they were first used as tracers by Hevesey. - Both stable - and radioactive isotopes were utilized in early investigations, but the situation changed dramatically with the invention of the cyclotron by Lawrence in 1930 and the construction of the nuclear reactor by Fermi in 1942 that enabled access to radioisotopes on a regular basis. Radioisotope use in medicine was also accelerated by advances in radiation-detection techniques. The development of single-photon emission computerized tomography (SPECT) " and positron emission tomography revolutionized... 

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