Soft-tissue tumors malignant

The Wilms tumor-1 (WTl) gene is located on the short arm of chromosome 11 (llpl3). It encodes a protein that is a critical determinant of urogenital development and is expressed in >80% of nephroblastomas. With regard to osseous and soft tissue tumors, WTl protein is not a specific marker and is potentially present in angiosarcoma, malignant peripheral nerve sheath tumor, synovial sarcoma, osteosarcoma, myxoid liposarcoma, and clear-cell sarcoma.Nevertheless, it is most often utilized (in a structured panel with other immunodeter-minants) as an adjunctive indicator of endothelial differentiation in diagnostic practice. ... 

One of the greatest challenges in the realm of bone and soft tissue tumor pathology is the reliable recognition of osseous matrix production in malignant... 

Weiss SW, Langloss JM, Enzinger EM. Value of SlOO protein in the diagnosis of soft tissue tumors, with particular reference to benign and malignant Schwann cell tumors. Lab Invest. 1983 49 299-308. 

Sirgi KE, Wick MR, Swanson PE. B72.3 and CD34 immuno-reactivity in malignant epitlielioid soft tissue tumors Adjuncts in the recognition of endothelial neoplasms. Am J Surg Pathol. 1993 17 179-185. 

Zelger BG, Steiner H, Wambacher B, et al. Malignant melanomas simulating various types of soft tissue tumors. Dermatol Surg. 1997 23 1047-1054. 

Hoot AC, Russo P, Judkins AR, et al. Immunohistochemical analysis of hSNF5dNIl distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors. Am J Surg Pathol. 2004 28 1485-1491. 

Synovial sarcoma is a highly malignant soft tissue tumor, arises in different locations mainly in the intra- and para-articular region, accounts about 10-15% of all soft tissue sarcomas and occurs most commonly in young adults between... 

Rhabdomyosarcoma is a malignant soft tissue tumor derived from primitive mesenchymal cells with tendency to skeletal muscle differentiation. According to the international classification, rhabdomyosarcoma is classified into three major types based on morphological features, cytogenetic properties and clinical behavior ... 

Measurement of the catecholamines and a variety of the intermediate metabolites in blood or tissue is common in psychiatric and neurochemical research. In clinical chemistry the major interest in catecholamine metabolism surrounds the detection and location of the tumors of neural crest origin -phaeochromocytoma and neuroblastoma. These tumors are fortunately rare but their identification is important because if treated promptly they may be curable. Phaeochromocytoma is associated with secretion of adrenaline and/or noradrenaline into the bloodstream and can either be detected by the increase in the parent compounds or by increased VMA excretion. The most common presentation by the patient is hypertension unresponsive to conventional therapy. Neuroblastoma is the commonest malignant soft tissue tumor of childhood, arising from ectodermal neuroblasts. These tumors secrete abnormally high concentrations of dopamine which is largely metabolized to HVA. 

Swann, M. (1984) Malignant soft tissue tumor at the site of a total hip replacement. J. Bone Joint Surg. 66B, 269-231. 

It is indicated in GI tract carcinoma, acute myeloblastic leukaemia, bronchogenic, breast and ovarian carcinoma, soft tissue and bone sarcomas, malignant lymphoma primary management of nonmetastatic bladder carcinoma (intravesical administration), Wilm s tumor and neuroblastoma. 

Eriksson M, Hardell L, Berg NO, et al. 1979. Case-control study on malignant mesenchymal tumors of the soft tissue and exposure to chemical substances. Lakartidningen 76 3872-3875. 

Since Franklin s original description of y-chain disease, a total of 17 cases are now known (F7), and tumors producing a-chain (some 20 cases) and / -chain (some 4 cases) have been found. All these tumors have been primarily in the soft tissues, either as malignant plasmacytoma or lymphoma, with little if any involvement of bone. In common with other malignant immunocytomata, immune paresis is the rule and infection is often a cause of death. 

Anti-CD99 (M) Dako 1 20 MWER Recognition of virtually all primitive neuroectodermal tumors and Ewing s sarcomas labels roughly 50% of synovial sarcomas and malignant peripheral nerve sheath tumors also present in lymphoblastic lymphomas/ leukemias presenting in soft tissue... 

TABLE 4.4 Percentages of Positivity for Pertinent Immunoreactants in Malignant Small Round Cell Tumors of Soft Tissue and Bone ... 

Aggressive angiomyxoma (AAM) is a peculiar neoplasm of the pelvic and perineal soft tissues that most commonly affects women. It is composed of loosely arranged, bland spindled to stellate cells embedded in a myxoid matrix punctuated by numerous venule- and capillary-sized blood vessels reminiscent of myxoid liposarcoma (Fig. 4.8). The vascular pattern of AAM lacks the arborizing appearance that is seen in some overtly malignant myxoid tumors. Some morphologic and immunophenotypic features of aggressive AAM also are shared in part by intramuscular myxoma. 

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