Papillary thyroid cancer

Whatever the mechanism may be, the high incidence of associated papillary thyroid cancer mandates at a minimum that one ask about the use of minocycline in any patient who has an enlarged thyroid. The authors recommended that if a patient has taken minocycline in the past, biopsy and possibly removal of the thyroid gland is advisable. 

Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA (2008) Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J Endocrinol 199(2) 243-252... 

Frattini M, Ferrario C, Bressan P, et al. Alternative mutations of BRAF, RET and NTRKl are associated with similar but distinct gene expression patterns in papillary thyroid cancer. Oncogene. 2004 23 7426-7440. 

Pax-8 in the nucleus is likely required for the full activation of Pax-8. Decreased Ref-1 localization in the nuclei, however, has been observed in some thyroid cancer cells and tissues (Russo et at, 2001). In addition, somatic rearrangements of the RET receptor (rearranged in transforma-tion/papillary thyroid carcinoma, RET/PTC), frequently observed in papillary thyroid cancer, impair the activity of Pax-8 (De Vita ij /., 1998). 

E. Follicular and anaplastic thyroid cancer E. Papillary thyroid cancer ... 

In case malignancy has not been known prior to the operation and is incidentally discovered by histological workup, the patient will be reoperated within 4-7 days to complete total thyroidectomy. One exception applies in younger adults with papillary thyroid cancer measuring less than 1 cm, who show no indications of nodular or metastatic spread of the disease, where, because of the excellent prognosis, there may be no need for total thyroidectomy and subsequent radioiodine treatment. 

Iodine prophylaxis has also affected the frequency and type of thyroid cancers. Following its introduction, a decrease was noted in the number of cases of folhcular and anaplastic thyroid cancer. At the same time, an increase in diagnoses of papillary thyroid cancer was found. Similar changes were observed in other countries, where the effects of iodine deficiency were eliminated (Zonenberg et al, 2006). An additional association between iodine supply and decrease in the incidence of stomach cancer has been observed however, further studies are necessary (Gofkowski et al, 2007). 

In contrast to the overall incidence of thyroid cancer, the types of cancer change if an area goes from an IDA to an ISA. In ISAs anaplastic thyroid cancer is rare and the main type of DTC is papillary thyroid cancer. The ratio between papillary and follicular thyroid cancer ranges from 6.5 to... 

Increase in iodine supply changes the histological type of thyroid cancer sufficient iodine supply leads to an increase of papillary thyroid cancer, a thyroid cancer type with a better prognosis. Follicular thyroid cancer, dedifferentiated follicular thyroid cancer, and anaplastic cancer have become less frequent in Austria. 

No cases of thyroid cancer were identified in MDI or MAI at baseline however, 10 subjects (1 man and 9 women) were found to have papillary carcinoma in El, the region with excessive intake of iodine. All these 10 cases were found after 1994. Between 1999 and 2004, 13 cases of papillary thyroid cancer (PTC) were diagnosed again in El (2 men and 11 women), but none were diagnosed in MDI and MAI. 

Lin Ci DuJ, Shen WT, Whang EE, Donner DB, Griff N, He F, Jar Moor FD, Clark OH, Ruan DT. Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-tike activity in papillary thyroid cancer. J Clin Endocrinol Metab. 2011 96 E554-65. 

Case report of sialadenitis following I therapy for papillary thyroid cancer... 

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