Gastric sodium iodide symporter

The perchlorate ion of potassium perchlorate, KCIO4, is a competitive inhibitor of thyroidal 1 transport via the Sodium Iodide Symporter (NIS).This drug can cause fatal aplastic anemia and gastric ulcers and is now rarely used. If administered with careful supervision, in limited low doses and for only brief periods, serious toxic effects can be avoided. The compound is especially effective in treating iodine-induced hyperthyroidism, which may occur, for example, in patients treated with the antiar-rhythmic compound amiodarone. Perchlorate ion can also be used in a diagnostic test of 1 incorporation into Tg, the so-called perchlorate discharge test. 

Sodium Iodide Symporter (NIS) in Gastric Mucosa Gastric Iodide Secretion... 

In the thyroid gland iodide is actively transported into the thyrocyte by the sodium iodide symporter (NIS). The transport of iodide against a gradient is powered by Na /K -ATPase, and competitively inhibited by perchlorate (see review by Carrasco, 1993). With the revelation of the complementary deoxyribonucleic acid (cDNA)-sequence of rat-NIS (Dai et ai, 1996), soon followed by the sequencing of human NIS (Smanik cT gastric wall and the cDNA-sequence of human gastric NIS was revealed (Spitzweg et ai, 1998). 

The sodium iodide-symporter (NIS) has been detected in gastric mucosa by immunohistochemistry, in situ hybridization and the combination of RT-PCR and southern blot. 

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