Sodium Diphosphate

A mixture of 24 g of 1,3-dimethyladamantane and 80 ml of bromine was refluxed for 6 hours. The reaction product mixture was cooled, taken up in about 200 ml of chloroform, and poured onto ice. The excess bromine was removed by adding sodium hydrosulfite. The chloroform layer was separated from the aqueous layer, dried, concentrated in vacuo, and distilled at reduced pressure to yield 30.5 g of product having a boiling point of about 118°C at 5-6 mm n = 1.5169-1.5182. The product was identified by nuclear magnetic resonance (NMR) and elemental analyses as 1-bromo-3,5-dimethyladamantane. 

A mixture of 20 g of 1-bromo-3,5-dimethyladamantane, 75 ml of acetonitrile,and 150 ml of concentrated sulfuric acid was allowed to react overnight at ambient room temperature. The red reaction product mixture was poured over crushed ice, and the white solid which precipitated was taken up in benzene and the benzene solution dried over sodium hydroxide pellets. The benzene solution was filtered from the drying agent and evaporated to dryness in vacuo to yield 18.2 g of product having a melting point of about 97°C and identified by infrared spectrum as 1-acetamido-3,5-dimethyladamantane. 

A mixture of 18 g of 1-acetamido 3,5-dimethyladamantane, 38 g of sodium hydroxide, and 300 ml of diethylene glycol was refluxed for a period of 6 hours. The reaction product mixture was cooled and poured onto about 2,000 ml of crushed ice. The basic solution thus obtained was extracted five times with 250-ml portions of benzene and the aqueous layer was discarded. The combined benzene extracts were dried over sodium hydroxide and the dried benzene solution concentrated in vacuo to give a crude oil weighing 14 g and having n = 

A 4 g sample of the crude oil was dissolved In ether and the solution saturated with anhydrous hydrogen chloride. The solid which precipitated was filtered off and recrystallized from a mixture of alcohol and ether to yield product weigh ing 3.5 g and melting at 258°C. It was identified by analysis as 1 -amino-3,5-dimethyladamantane hydrochloride. 

Chemical Name 2-Methyl-1,4-naphthalenediol diphosphoric acid ester tetrasodium salt Common Name — 

and Krumkalns, E. U.S. Patent 3,391,142 July 2, 196B assigned to Eli Lilly Co. 

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Synonyms Sodium pyrophosphate tetra-sodium diphosphate TSPP... 

Sodium diphosphate is prepared by the following procedure. Disodium hydrogen phosphate dihydrate, Na2HP04 2H20, (7.12 g, 40 mmole) is placed in a 60-mL platinum crucible and heated in air at 400° for 12 hours (Product Merck for analysis K 6580). According to Porthault,2 this method leads to a tetrasodium diphosphate, Na4P207, the purity of which is better than 99.5%. No impurities can be found by chromatographic or potentiometric analysis. 

Sodium diimidotrimetaphosphate, Na3P308(NH)2, formation and basic hydrolysis of, in preparation of pentasodium diimido-triphosphate, 6 105ra., 106 Sodium diimidotriphosphate, Na5P308(NH)2-6H20, 6 104 Sodium diphosphates, 3 98, 99, 100 Sodium dithionate, 2 170 Sodium (ethylenediaminetetra-acetato)cobaltate(III), 5 186 Sodium hexafluorophosphate, 3 111, 115... 

CnH1(102 481-85-6) see Menadiol sodium diphosphate menadiol 1-acetate... 

FIG. 10 Influence of dispergent agent, i.e., sodium diphosphate (squares) and sodium hydroxide (circles) on the remoulded shear strength, Hu (solid lines), as well as the conductivity, t, (dashed lines) of kaolin. The lines are redrawn from Soderblom [42]. 

We have already discussed the properties of human erythrocytic acid phosphatase (Section 3.3), and we pointed out that, like acid phosphate in other tissues, it may exist in several isoenzymatic forms. In 1963, Hopkinson et al. (H13) subjected hemolysates of human red cells from an English population to horizontal starch-gel electrophoresis for 17 hours at 5°C. The gels were then sliced horizontally, covered with 0.05 M phenolphthalein sodium diphosphate at pH 6.0, and allowed to incubate for 3 hours at 37°C. Five different electrophoretic patterns of acid phosphatase activity could be distinguished in different individuals. Shortly thereafter Lai and his associates (L2) confirmed these findings and discovered an additional sixth pattern which had been predicted by Hopkinson et al. (H13). The distribution of these patterns in various types of population was assiduously pursued within the next several years, and several new ones were discovered in Negro populations (G3, K2). 

Helson L. The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors. Thromb Res 1984 35(1) 11-18. 

Variations of this polymerization reaction are exhibited by potassium and sodium salts because of topochemical reasons and because of the greater stability of crystalline sodium diphosphate and sodium trimetaphosphate. Of interest to this discussion is the sequence of reactions on... 

Humulin BR Zinc crystalline insulin dissolved in sodium diphosphate buffer Rapid onset, short duration use in pumps only... 

Menadiol Sodium Diphosphate, USP. Menadiol sodium diphosphate, letrastxlium 2-methyl-1.4-nuphthalene-diol bis(dihydrogen phosphate), tetrasodium 2-mcthylnuph-thohydroquinone diphosphate, vitamin K4. is a white hygroscopic powder, very soluble in water, giving solutions with a pH of 7 to 9. It is available in ampuls for use subcutaneously, intramuscularly, or intravenously and in tablets for oral administration. Unlike the other vitamin K analogues, menadiol oral absorption does not depend on the presence of bile. Once absorbed, it is converted to inenadione. 

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