Diphosphoric acid esters

Chemical Name 2-Methyl-l, 4-naphthalenediol diphosphoric acid ester tetrasodium salt Common Name —... 

The mono- and diphosphoric acid esters of the sugars are particularly important in enzymatic carbohydrate metabolism. The phosphate group is attached to the glycosidic... 

There has long been the belief that DES may have a direct local action on the prostatic cancer, and it has been claimed [40] that orchidectomy and DES was clinically more effective than either form of therapy alone. The rationale behind the use of fosfestrol (DES 4,4 -diphosphoric acid ester, Honvan, (2)) in large doses (200 mg daily) is that the free and locally active form of the drug DES would be released within the tissue by the high concentrations of phosphatases present in prostatic cells. There is little evidence that fosfestrol accumulates in the prostate or that DES is released in reasonable concentrations [41]. Such evidence, however, still does not preclude the possibility that DES has a cytotoxic action in the prostatic cell and studies continue to attempt to identify this effect. 

The hemolytic effect of menadione may be demonstrated also in vitro with red blood cells obtained from vitamin E-deficient rats (Rose and Gyorgy, 1960). This was first shown in vivo by Allison el al. (1956). The tetrasodium salt of the diphosphoric acid ester of 2-methyl-l, 4-naphthohydroquinone (Synkayvite ) was inactive in vitro but produced hemolysis after pretreatment with phosphatase (Rose and Gyorgy, 1960). The natural vitamin Ki was inactive in vivo as well as in vitro. Vitamin E prevents the hemolysis by vitamin K derivatives. In agreement with Nitowsky and Marks, it is... 

Diphosphoric acids from diphosphoric acid esters... 

Diphosphoric acid esters—Nucleoside diphosphates s. 16, 167 labeling of... 

Diphosphoric acid esters from phosphoromorpholidates Nucleoside diphosphates... 

Pyridine Diphosphoric acids from diphosphoric acid esters by interchange s. 19,150 CsH,N... 

Inter. . . s. a. Trans. . . Interchange (s. a. Exchange) diphosphoric acids from diphosphoric acid esters 19, 150... 

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