Smith, Kline and French

The demonstration unit was later transported to the CECOS faciHty at Niagara Falls, New York. In tests performed in 1985, approximately 3400 L of a mixed waste containing 2-chlorophenol [95-57-8] nitrobenzene [98-95-3] and 1,1,2-trichloroethane [79-00-5] were processed over 145 operating hours 2-propanol was used as a supplemental fuel the temperature was maintained at 615 to 635°C. Another 95-h test was conducted on a PCB containing transformer waste. Very high destmction efficiencies were achieved for all compounds studied (17). A later bench-scale study, conducted at Smith Kline and French Laboratories in conjunction with Modar (18), showed that simulated chemical and biological wastes, a fermentation broth, and extreme thermophilic bacteria were all completely destroyed within detection limits. 

National Research Council of Canada Post-doctorate FeUow, 1954-56, at the University of Ottawa, Ottawa, Ontario. Present address Smith, Kline and French Ltd., Welwyn Garden City, Herts, England. 

Smith Kline and French Laboratories, Philadelphia, Pennsylvania 19101. 

Smith Kline and French Research Institute, Welwyn Garden Gty, Herts. 

Wood, C. J. Simkins, M. A. Int. Svmp. on Histamine H2-Receptor Antagonists. 1973, Smith Kline and French Lab. Ltd., Welwyn, Garden City. 

Acknowledgments This work was supported in part by contract NOl-HD-2-2807 and grant HD-13527 from the National Institutes of Health, and grant PCM-8204908 from the National Science Foundation. Support from Smith Kline and French Laboratories is also gratefully acknowledged. 

Amphetamine (1) is a very simple phenethylamine, described in the chemical literature as early as 1887 (Edeleano, 1887). Smith, Kline and French (now GSK) filed a patent on the synthesis and use of amphetamine in 1930 (Nabenhauer, 1930), and the enantiomers were assigned in 1932 (Leithe, 1932 V-Braun and Friehmelt, 1933). Not surprisingly, early access to chiral material relied on classical crystallization-based resolutions (Gillingham, 1962 Nabenhaur, 1942). The early, racemic syntheses of amphetamine fall into four major classifications according to the method used to make the C-N bond ... 

Amphetamine, a Schedule II drug, was synthesized by the German chemist . Edeleano in 1887 (Figure 6.2). The trade names for amphetamine are Benzedrine and Dexedrine. Smith, Kline, and French marketed Benzedrine inhaler in the 1930s for respiratory disorders. Since amphetamine decreases drowsiness and fatigue, it is marketed for narcolepsy and attention-deficit/hyperactivity disorder (ADHD), and was used as an appetite suppressant (anorectic) in diet regimens. Amphetamine was supplied to the... 

Bioinorganic Chemistry of Gold Coordination Compounds , ed. B. M. Sutton and R. G. Franz, Smith, Kline and French, Philadelphia, 1983. 

Jribdelin (AAD-609 complex) Kibdelosporangium aridum subsp. largutn ATCC 39922 1985 Smith, Kline and French... 

Pharmaceutical manufacturer Smith, Kline and French introduced Benzedrine, an over-the-counter amphetamine based inhaler for relieving nasal congestion. 

In 1952, Smith, Kline and French introduced the stimulant Dexedrine (dextroamphetamine sulfate) for narcolepsy in the United States. It was manufactured as a Spansule, the first time-release capsule, which gradually released the drug over a period of time. 

Begosh, P., Smith Kline and French Labs., Phila., PA, unpublished data. 

R. Lee Webb, Clifford S. Labaw, and George R. Wellman—Smith Kline and French Laboratories, Organic Chemistry Department, 1500 Spring Garden Street, Philadelphia, PA 19101... 

FR Patent No. 1,442,295 Oct. 8, 1964 Assigned to Smith Kline and French Laboratories residant aux Etats-Unis dAmerique... 

Assigned to Smith Kline and French Laboratories Nemeth, P.E. and Sutton, B.M. US Patent 3,635,945 January 18, 1972 Assigned to Smith Kline and French Laboratories... 

Durant, G.J., Emmett, J.C. and Ganellin, C.R. US Patent 3,876,647 April 8, 1975 assigned to Smith Kline and French Laboratories Limited... 

Nabenhauer, F.R US Patent 2,276,508 March 17, 1942 assigned to Smith, Kline and French Laboratories... 

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