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Smith Kline French

At Smith Kline French a general approach to cephalosporin and penicillin nuclear analogs was developed that utilizes a monocyclic /3-lactam (59) with the correct cis stereochemistry as a key intermediate. This is prepared by reaction of the mixed anhydride of azidoacetic acid and trifluoroacetic acid with imine (58) followed by oxidative removal of the dimethoxybenzyl group. This product could be further elaborated to intermediate (60) which, on reaction with a -bromoketones, provides isocephalosporins (61). These nuclear analogs displayed antibacterial properties similar to cephalosporins (b-79MI51000). [Pg.295]

Durant, G.J., Emmett, J.C. and Ganellin, C.R. U.S. Patent 3)876,647 April 8, 1975 assigned to Smith Kline French Laboratories Limited... [Pg.342]

Nabenhauer, F.P. U.S. Patent 2,276,508 March 17, 1942 assigned to Smith, Kline French Laboratories... [Pg.459]

Smith Kline French Laboratories British Patent 861,809 March 1,1961... [Pg.662]

U.S. Patent 3100207,1963 Zirkle.C.L. (Smith Kline French Laboratories) Chem. Abstr. 1964, 60, 1719. [Pg.63]

F Ridauran (Robapharm) 1 Ridaura (Smith Kline French 1984) Beecham 1985)... [Pg.154]

USA Anspor (Smith Kline French 1974) wfm Cephradine (Lederle Standard)... [Pg.399]

Clavucar (Smith Kline French)-comb. with ticarcilline... [Pg.495]

Histryl (Smith Kline French) wfm Lergoban (Riker) wfm... [Pg.680]

See other pages where Smith Kline French is mentioned: [Pg.241]    [Pg.220]    [Pg.55]    [Pg.154]    [Pg.154]    [Pg.350]    [Pg.471]    [Pg.471]    [Pg.471]    [Pg.471]    [Pg.471]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.472]    [Pg.495]    [Pg.542]    [Pg.638]    [Pg.904]    [Pg.904]    [Pg.904]    [Pg.906]   
See also in sourсe #XX -- [ Pg.44 , Pg.58 , Pg.67 , Pg.70 ]

See also in sourсe #XX -- [ Pg.22 ]



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Smith Kline and French

Smith, Kline French Laboratories

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